Muscarinic Agonists

Question 1

Quaternary nitrogen structure

Answer 1

Muscarine

Question 2

Alkaloid of wild mushroom of the Clitocybe
and Inocybe genera
Pure muscarinic activity
Resistant to hydrolysis (no ester moiety)
No therapeutic use (extremely potent)
Poisoning treated with anti-muscarinic drugs

Answer 2

Muscarine

Question 3

Non-selective muscarinic receptor agonist

Answer 3

Pilocarpine

Question 4

Alkaloid of South American shrub Pilocarpus jaborandi
Purely muscarinic activity
Crosses BBB

Answer 4

Pilocarpine

Question 5

Rx: dry mouth and neck from radiotherapy
or Sjogren’s syndrome, also open angle glaucoma, acute and chronic angle-closure glaucoma
Toxicity: excess muscarnic activation (slowed AV
conduction), hypotension, excessive
salivation and bronchoconstriction

Answer 5

Pilocarpine