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Pharm Block 1 > Adrenergic Antagonists > Flashcards

Adrenergic Antagonists Flashcards

1
Q

Non-selective b-blockers

A

Propranolol/Nadolol/Timolol

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2
Q

Physiological effects

	Decreased HR
	Decreased contractility
	Decreased renin release
	Reduced sympathetic activation
	Inhibition of aqueous humor 
		production

Toxicity

Bronchospasm
Mask symptoms of hypoglycemia
Bradycardia
A

Propranolol/Nadolol/Timolol

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3
Q

Indications

	Hypertension
	Angina
	Glaucoma
	Early to moderate Heart Failure
	Arrhythmia
	Thyrotoxicosis
	Anxiety

Contraindications

Bronchospasm during asthma
Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic Shock
A

Propranolol/Nadolol/Timolol

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4
Q

Cardioselective b1-blockers

A

Metoprolol, Atenolol, Esmolol (emergent

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5
Q

Physiological effects

Decrease HR
Decrease contractility
Decrease renin release
Decreased sympathetic 	activation

Toxicity
Hypotension
Bradycardia

A

Metoprolol, Atenolol, Esmolol (emergent

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6
Q

Indications

Hypertension
Angina
Arrhythmia

Contraindications

Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic Shock
A

Metoprolol, Atenolol, Esmolol (emergent

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7
Q

Partial Agonist b-blockers

A

Pindolol (less bradycardia and lipid abnormalities)

beneficial when sympathetic activity is high)

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8
Q

Physiological effects

Decrease BP
Decrease contractility
Decrease renin release
Decreased sympathetic activation

Toxicity
Hypotension
Indications

Hypertension

Contraindications

Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic Shock
A

Pindolol (less bradycardia and lipid abnormalities)

beneficial when sympathetic activity is high)

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9
Q

Non-selective a-blockers

A

Phentolamine (reversible), Phenoxybenzamine (irreversible

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10
Q

Physiological effects

Decreased BP (a blockade + unmasks B effects)

Increased chronotropy
	and inotropy

Toxicity
Prolonged hypotension
Reflex tachycardia

A

Phentolamine (reversible), Phenoxybenzamine (irreversible

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11
Q

Indications
Hypertension associated w/ pheochromocytoma
Vasoconstrictor-induced extravasation

Contraindications
Coronary artery disease

A

Phentolamine (reversible), Phenoxybenzamine (irreversible

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12
Q

Selective a1 adrenergic blockers

A

Prazosin/Doxazosin/Terazosin

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13
Q

Physiological effects

Inhibits vasoconstriction
Prostate smooth muscle 	relaxation Indications

Hypertension 
Benign prostatic hyperplasia (BPH)

Toxicity
Orthostatic hypotension

A

Prazosin/Doxazosin/Terazosin

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Pharm Block 1 (11 decks)

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