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Block 1 Flashcards

1
Q

Stimulates a1 a2 B1 B2

A

Epinephrine

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2
Q 
Low dose 
		lower diastolic BP 
		Increase CO
	Higher dose
		Increase TPR and CO
	Bronchodilation 
	Decreased bronchial 	secretions
A

Epinephrine

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3
Q

Toxicity

Arrhythmias

A

Epinephrine

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4
Q

Indications (therapeutic uses)
Anaphylaxis
Cardiac Arrest
Bronchospasm

Contraindications
Later term pregnancy

A

Epinephrine

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5
Q

stimulates a1, a2 and b1 receptors

A

NE

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6
Q

Physiological effects

Increase CO 
Increase TPR
Decrease HR (baroreflex)
Overall increase MAP
A

NE

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7
Q

Toxicity

ISCHEMIA

A

NE

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8
Q

Indications

Limited to shock

Contraindications

pre-existing vaso-
constriction or ischemia

A

NE

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9
Q

stimulates D1,D2, b1, a1 and a2

A

Dopamine

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10
Q

Physiological effects

	Low rates
		Decreases TPR  D1
		Increases CO B1
	Higher rates
		Increases MAP and TPR a1 a2 B1
A

Dopamine

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11
Q

Toxicity

	Low BP (at low infusion rates)
	Ischemia (high infusion rates)
A

Dopamine

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12
Q

Indications

Cardiogenic Shock

Contraindications

Tachyarrhythmias
Ventricular fibrillation
A

Dopamine

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13
Q

stimulates b1 and b2 adrenergic receptors)

A

Isoproterenol

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14
Q

Physiological effects

Decrease TPR  B2
Increase CO B1
Small decrease in MAP
Bronchodilation B2
A

Isoproterenol

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15
Q

Toxicity

Tachyarrhythmias
A

Isoproterenol

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16
Q

Indications

Bradycardia/heart block 	when TPR is high

Contraindications

Angina w/ arrhythmias
A

Isoproterenol

17
Q

affinity b1>b2>a; at appropriate doses is

considered a selective b1 agonist)

A

Dobutamine

18
Q

Physiological effects

Increase CO b1

Toxicity

Hypotension  B2
A

Dobutamine

19
Q

Indications

Short-term Rx for CHF or 
cardiogenic shock
excess b-blockade
A

Dobutamine

20
Q

b2-agonists

A

Terbutaline and Albuterol

21
Q

Physiological effects

Bronchodilation
Uterine relaxation

Toxicity

Tachycardia
Muscle Tremor
Tolerance
A

Terbutaline and Albuterol

22
Q

Indications

Bronchospasm
Chronic Rx of obstructive airway Dx
A

Terbutaline and Albuterol

23
Q

selective a1 receptor agonist

A

Phenylephrine

24
Q

Physiological effects

Increase TPR and MAP
Decrease HR (baroreflex)
Pupillary dilation
Decrease bronchiole and 	sinus secretions

Toxicity

Hypertension
A

Phenylephrine

25
Q

Indications

Hypotension during anesthesia
SV tachycardia
Mydriatic agent in ophthalmic Rx
Nasal congestion

Contraindications

Hypertension
Ventricular tachycardia
A

Phenylephrine

26
Q

selective a2 adrenergic

receptor agonist

27
Q

Physiological effects

Acute increase in BP
	(peripheral effect)
Reduced BP (central effect)

Toxicity

Dry mouth
Hypertensive crisis
	(after acute withdrawal)

Indications

Hypertension due to sympathetic
	activation

Pharm Block 1 (11 decks)

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