Block 1 Flashcards
Stimulates a1 a2 B1 B2
Epinephrine
Low dose lower diastolic BP Increase CO Higher dose Increase TPR and CO Bronchodilation Decreased bronchial secretions
Epinephrine
Toxicity
Arrhythmias
Epinephrine
Indications (therapeutic uses)
Anaphylaxis
Cardiac Arrest
Bronchospasm
Contraindications
Later term pregnancy
Epinephrine
stimulates a1, a2 and b1 receptors
NE
Physiological effects
Increase CO Increase TPR Decrease HR (baroreflex) Overall increase MAP
NE
Toxicity
ISCHEMIA
NE
Indications
Limited to shock
Contraindications
pre-existing vaso-
constriction or ischemia
NE
stimulates D1,D2, b1, a1 and a2
Dopamine
Physiological effects
Low rates Decreases TPR D1 Increases CO B1 Higher rates Increases MAP and TPR a1 a2 B1
Dopamine
Toxicity
Low BP (at low infusion rates) Ischemia (high infusion rates)
Dopamine
Indications
Cardiogenic Shock
Contraindications
Tachyarrhythmias Ventricular fibrillation
Dopamine
stimulates b1 and b2 adrenergic receptors)
Isoproterenol
Physiological effects
Decrease TPR B2 Increase CO B1 Small decrease in MAP Bronchodilation B2
Isoproterenol
Toxicity
Tachyarrhythmias
Isoproterenol
Indications
Bradycardia/heart block when TPR is high
Contraindications
Angina w/ arrhythmias
Isoproterenol
affinity b1>b2>a; at appropriate doses is
considered a selective b1 agonist)
Dobutamine
Physiological effects
Increase CO b1
Toxicity
Hypotension B2
Dobutamine
Indications
Short-term Rx for CHF or cardiogenic shock excess b-blockade
Dobutamine
b2-agonists
Terbutaline and Albuterol
Physiological effects
Bronchodilation Uterine relaxation
Toxicity
Tachycardia Muscle Tremor Tolerance
Terbutaline and Albuterol
Indications
Bronchospasm Chronic Rx of obstructive airway Dx
Terbutaline and Albuterol
selective a1 receptor agonist
Phenylephrine
Physiological effects
Increase TPR and MAP Decrease HR (baroreflex) Pupillary dilation Decrease bronchiole and sinus secretions
Toxicity
Hypertension
Phenylephrine
