munson 1 pdf Flashcards
Typical Blood Level Versus Time Curve where is the Cmax and Tmax
where drug blood/ plasma levels is greatest
what is in the disposition phase
distributino
what is in the elimination phase
metabolism and excretion
where do you usually measure blood plasma levels
arm
Absorption rate (kabs ) is defined by the drug properties, the excipient/drug composition of the formulation, and the physiological barriers between the GI tract and systemic circulation
the 3 components of druggability
-discovery stage
-assesses the ability of NCEs to bind to the drug target
-in this stage, in vivo models are used to assess
Development’s three components
-refers drug product performance
-incorporates factors like biorelevant solubility and dissolution
-formulation factors related to ADME/T incorporated
how are druggable genes identified
by pharmacogenomic methods
druggable protein:
proteins that can bind drug like compounds with binding affinity below 10 mM
how are druggable genes modulated
