knipp lecture Flashcards
1
Q
mouth to anus transit time
A
24-32 hours
2
Q
small intestinal transit time
A
3 hours
3
Q
most absorption occurs where
A
small intestine
4
Q
small intestine pH
A
5-6.5
5
Q
colon drug absorption mainly occurs in what region
A
ascending region
6
Q
characteristics of intestine
A
- most transporters in SI
-upper SI= mixing
-lower SI= electrolyte
-colon= fluid electrolyte absorption
7
Q
stomach compartments
A
- fundus (gas)
-body (storage) - antrum-lowest part of stomach
8
Q
oral cavity epithelia
A
stratified squamous epithelium
9
Q
esophagus epithelium
A
stratified squamous epithelium
10
Q
trachea epithelia
A
pseudostratified squamous
10
Q
stomach epithelium
A
columnar epithelial cells
11
Q
large and small intestines
A
columnar epithelial cells
12
Q
lower rectum epithelia
A
stratified squamous non-keratinized to keratinized
12
Q
upper rectum epithelia
A
simple columnar
13
Q
solute carrier (SLC)
A
-43 subfamilies
->300 members
-generally influx or secretory efflux transporters
-PepT1, OATs, OATPs
