Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK > Multisystem Autoimmune Disease > Flashcards

Multisystem Autoimmune Disease Flashcards

1
Q

true or false

system lupus erythematous affects women more than men

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how does SLE affect the nervous system?

A 
> cranial nerve lesions
> peripheral neuropathy
> ataxia
> fits
> hemiplegia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

describe the rash often presenting on the face in SLE

A

a butterfly rash across the nose and cheeks (photosensitive)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what skin changes may be seen in SLE?

A

> vasculitis
purpura
urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

how may SLE affect the chest?

A

> fibrosis
effusions
pleurisy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how may SLE affect the joints?

A

> arthritis of the small joints

> aseptic necrosis of the hip

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how may SLE affect the blood?

A

> anaemia
leukopenia
thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

true or false

SLE can cause Raynaud’s

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what affect does SLE have on the heart?

A

> pericarditis
endocarditis
aortic valve lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

true or false

SLE causes increase in hair growth

A

false it can cause alopecia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

true or false

scleroderma affects men more than women

A

false

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

in limited scleroderma to what is the disease limited to?

A

the hands and forearms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

how does scleroderma present?

A 
> raynauds
> oesophageal thickening
> abnormal peristalsis
> sclerodactyly
> telangiectasia
> morphea
> calcinosis (calcium deposits, very sore)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

describe diffuse scleroderma

A

this is the same as limited except across the whole body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is a complication of limited scleroderma?

A

pulmonary hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are some complications of diffuse scleroderma>

A

> small bowel bacterial overgrowth
renal crisis
pulmonary fibrosis

17
Q

what changes occur to the parotid gland in sjogrens syndrome?

A

there is emlargement

18
Q

what systemic systems may occur in sjogrens syndrome?

A

> fatigue
fever
myalgia
arthralgia

19
Q

what GI symptoms occur in sjogrens syndrome?

A

> dysphagia

> abnormal oesophageal motility

20
Q

what resp. conditions occur in sjogrens syndrome?

A

interstitial lung disease

21
Q

how does sjogrens syndrome affect the peripheral nervous system?

A

> sensory neuropathy

> mononeuritis multiplex

22
Q

how does sjogrens syndrome affect he central nervous system?

A

> fits
ataxia
hemiplegia
cranial nerve lesion

23
Q

how does sjogrens syndrome affect the skin?

A

> palpable purpura

> raynauds syndrome

24
Q

what are the joint manifestations of sjogrens syndrome?

A

arthralgia

25
Q

how does sjogrens syndrome affect the kidneys?

A

it causes tubular necrosis

26
Q

what complications can occur in sjogrens syndrome?

A

> lymphoma
neuropathy
interstitial lung disease
renal tubular acidosis

27
Q

how does autoimmune myositis present?

A

muscle weakness
> diffuse
> proximal
> symmetrical

dermamyositis
> gottrons papules

polymyositis

28
Q

what are the complications of autoimmune myositis?

A

> interstitial lung disease

> cancer

29
Q

what is the classification criteria for giant cell arteritis?

A 
3 or more of:
> ESR 50 or more
> abnormal temporal biopsy
> tender temporal artery
> reduced pulsation of the temporal artery
> more than 50 years of age
30
Q

name some ANCA associated vasculitis

A

> granulomatosis with polyangiitis
microscopic polyangiitis
eosinophilic granulomatosis

31
Q

what is granulomatosis with polyangiitis?

A

necrotising granulomatous inflammation usually involving the upper resp. tract

32
Q

how does granulomatosis polyangiitis commonly present?

A

necrotising glomerulonephritis

33
Q

what is microscopic polyangiitis?

A

necrotising fasciitis with few or no immune deposits. necrotising arteries may be present and granulomatous inflammation is absent

34
Q

what is eosinophilic granulomatosis with polyangiitis?

A

eosinophilic rich and necrotising granulomatous inflammation often involving the resp. tract

35
Q

what is the 5 year damage of ANCA associated vasculitis?

A 
> end stage renal disease
> hearing loss
> lung damage
> malignancy
> nerve damage
36
Q

how might you treat mild multisystem autoimmune disease?

A

hydrocychlorquine

37
Q

how may you treat moderate multisystem autoimmune disease?

A

> methotrexate
azathioprine
mycophenolate

38
Q

what might you treat severe multisystem autoimmune disease?

A

> cyclophosphamide

> rituximab

MSK (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions