Multiple Sclerosis Falkenberg Flashcards
What is multiple sclerosis?
multiple scarred areas in the brain due to brain lesions in CNS due to demylination
What is the pathology of MS?
plaques-scars,lesions areas of inflammation infiltration of macrophages and T cells destruction of myelin axonal damage
Why do we get MS?
YOu have macrophages and lymphoctes and T cells and they get activated by an antigen. Attack oligodendrocytes and myelin
T/F
MS causes destruction of myelin as well as destruction of axons
T
What is the etiology of MS?
autoimmune disease
environmental
infectious
genetic
What is the age of onset of MS?
20-40 yrs
What is the most common neurological disease of young adults?
MS
Which gender is more likely to have MS?
females
2:1 ratio
Is there a genetic component in MS?
yes 1st degree relatives 10-20X risk
monozygotic twins 30% concordance
T/F
MS can be associated with where you lived the first 15 years of your life
T
T/F
Along the equator is high risk for MS
F
higher north the worst
Is the course of MS consitant b/w patients?
no it is variable between individuals
What are common symptoms of MS?
visual distubrances vertig limb weakness optic neuritis numbness fatigue pain
Is there cognitive impairment in MS patients?
not an impairment, just a slowing of cognitive function (i.e takes longer to find the answer)
What are the four main disease patterns of MS?
relapsing-remitting (RRMS) 75%
secondary progressive (SPMS)
primary progressive (PPMS) 10-15%
Progressive-Relapsing (PRMS)