Multiple Myeloma and Related Diseases

Question 1

High Risk cytogenetics for multiple myeloma

Answer 1

del (17p)
t(4;14)
t(14;16)
t(14;20)

Question 2

Diagnostic criteria for multiple myeloma

Answer 2

CRAB criteria OR
bone marrow plasmactosis > 60% OR
free kappa/lambda ratio > 100 or < 0.01 OR
bone lesions on imaging

Question 3

Baseline therapy for multiple myeloma

Answer 3

Triplet
Dexamethasone
Imid (revlimid, pomalyst)
proteasome inhibitor (bortezomib/velcade).

Question 4

What coagulopathy is associated with Amyloidosis?

Answer 4

Factor X deficiency - gets absorbed into amyloid fibrils.

Question 5

Most common locations of localized light chain amyloidosis.

Answer 5

Larynx
GU tract

Question 6

Treatment of localized light chain amyloidosis.

Answer 6

Local resection followed by observation.

Question 7

What is POEMS syndrome?

Answer 7

Paraneoplastic syndrome from underlying plasma cell disorder.
Polyneuropathy
Organomegaly
Endocrinopathy
M-Protein
Skin changes