High Grade Non-Hodgkin Lymphomas

Question 1

Name the high grade lymphomas.

Answer 1

DLBCL
Burkitt Lymphoma
HIV associated Lymphoma
T cell lymphomas

Question 2

What is needed for all HIV associated lymphomas?

Answer 2

IT chemotherapy

Question 3

NK cell marker

Answer 3

CD56+

Question 4

Most common location of NK cell lymphoma

Answer 4

Nose

Question 5

Sinus histiocytosis with massive lymphadenopathy.
80% have spontaneous improvement without treatment.
Cells stain positive for S100, CD163 and CD68.
Emperipolesis: presence of other cells in the cytoplasm of a cell without evidence of destruction.

Answer 5

Rosai-Dorfman Syndrome/Disease

Question 6

T cell lymphoma with hypergammaglobulinemia and + DAT.

Answer 6

Angioimmunoblastic T cell lymphoma

Question 7

Lymphoma associated with splenomegaly and use of TNF-a inhibitors/azathioprine for IBD

Answer 7

Hepatosplenic T cell lymphoma

Question 8

What type of lymphoma is HIV and HHV-8 associated and arises in body cavities?

Answer 8

Primary effusion lymphoma.
Pleural space, pericardium, peritoneum.
Everyone gets IT chemo and antiretroviral treatment.

Question 9

Burkitt Lymphoma translocation

Answer 9

t(8;14)

Question 10

First line treatment for Anaplastic large cell lymphoma?
Based on what trial?

Answer 10

A-CHP (brentuximab, cyclophosphamide, doxorubicin, prednisone) preferred over CHOP due to Echelon-2 trial.

Question 11

Second or later line treatment for ALK+ anaplastic large cell lymphoma.

Answer 11

Crizotinib, Lorlatinib

Question 12

What do you use to treat advanced stage NK/T cell lymphomas?

Answer 12

Asparaginse containing regiments. Typical anthracycline based regiments are less effective due to high levels of P-glycoprotein expression.