Multiple Myeloma Flashcards
1
Q
Multiple myeloma immunophenotype (3)
Difference in WM?
A
CD20- CD138+ CD38+
WM=> CD20+
2
Q
Standard Risk MM factors (2)
A
t11;14
hyperdiploidy
3
Q
Intermediate Risk MM (2)
A
t(4;14)
13q-
4
Q
High Risk MM (4)
A
del(17p)
t(14;16)
t(14;20)
p53
5
Q
Elotuzumab MOA
A
anti-SLAMF7 monoclonal antibody, activates NK cells
6
Q
Pabinostat MOA and AE (1)
A
non-selective HDAC inhibitor, prolonged QT interval
7
Q
Ixazomib MOA, AEs (3)
A
Oral proteasome inhibitor (like carfi/bort)
Rash, neuropathy, cytopenias
8
Q
Isatuximab MOA
A
Anti-CD38 monoclonal antibody (like dara)
9
Q
Definition of Solitary plasmacytoma (3)
A
- Biopsy proven solitary lesion of bone or soft tissue that demonstrates clonal plasma cells
- Less than 10% plasma cells on bone marrow biopsy
- No other end organ damage
