Lymphoma

Question 1

Which HL is CD20 +?

Answer 1

Nodular lymphocyte predominant type. Good prognosis

Question 2

FL translocation

Answer 2

t(14;18)-> Overexpression of BCL2

Question 3

mantle cell lymphoma translocation

Answer 3

t(11;14)-> Cyclin D1 overexpression

Question 4

Burkitt’s Lymphoma translocations (3)

Answer 4

t(2;8)
t(8;14)
t(8;22)
Fuse Ig Gene to c-MYC

Question 5

Protein overexpressed in germinal center type DLBCL

Answer 5

BCL6

Question 6

Anaplastic large cell lymphoma mutation

Answer 6

t(2;5)

Question 7

Marginal Zone Lymphoma translocation

Answer 7

t(11;18), MALT1 translocation

Question 8

Small intestine lymphoma infection

Answer 8

Campylobacter jejuni

Question 9

Lymphomas/diseases associated with HHV8 infection (3)

Answer 9

Castleman’s disease
Primary Effusion Lymphoma
Kaposi’s Sarcoma

Question 10

Infection associated with cutaneous MZL

Answer 10

borrelia burgdorferi

Question 11

HDAC inhibitor used in relapsed PTCL

Answer 11

belinostat

Question 12

disease where T cell receptor rearrangement is detected. How is this tested for?

Answer 12

LGL Leukemia

Southern blot

Question 13

Ab drug used for treatment of castleman’s disease

Answer 13

Siltuximab (anti-IL6)

Question 14

CLL/SLL Good Prognosis factors (2)

Answer 14

Mutated IgHV (Zap70 negative, CD 38 negative)
13q deletion

Question 15

CLL/SLL Bad prognostic features (4)

Answer 15

IgHV UNMUTATED
17p-
11q-
Complex karyotype

Question 16

Side effects of Idelalisib (3)

Answer 16

Hepatitis
Colitis
Pneumonitis