Multifactorial Inheritance

Question 0

Genotype

Answer 0

The genetic constitution of an individual as distinguished from the phenotype. More specifically the alleles present at one locus

Question 1

Allele

Answer 1

One of the alternative versions of gene or DNA sequence at a given locus

Question 2

Genome wide association study (GWAS)

Answer 2

A case-control study in which genetic variation, often measured as SNP genotypes is compared between people with a particular trait and unaffected individuals

Question 3

Haplotype

Answer 3

A set of DNA variations or polymorphisms that tend to be inherited together. A haplotype can refer to a combination of alleles or to a set of single nucleotide polymorphisms (SNPs) found on the same chromosome

Question 4

Linkage disequilibrium

Answer 4

In a population, co-occurrence of a specific DNA marker and a disease at a higher frequency than would be predicted by random chance

Question 5

Locus

Answer 5

The position occupied by a gene on a chromosome. Different forms of the gene (alleles) may occupy the locus

Question 6

Multifactorial inheritance

Answer 6

The type of non-Mendelian inheritance shown by traits that are determined by a combination of multiple factors, genetic and environmental. It is also termed complex inheritance. In principle, multifactorial inheritance can be polygenic (involving many genes at different loci) but it always has to be influenced by the environment

Question 7

Polygenic inheritance

Answer 7

Inheritance determined by many genes at different loci, with small additive effects; not to be confused with multifactorial inheritance, in which environmental as well as genetic factors may be involved