Multifactorial Inheritance Flashcards
Spina Bifida
Discontinuous Multifactorial Trait
Height , Weight, BP, Obesity, Cholesterol
Continuous Multifactorial Trait
Follows Gaussian Distribution
Continuous Multifactorial Trait
Threshold model of inheritance
Discontinuous Multifactorial Trait
Congenital malformations, cancer, CV disease
Discontinuous Multifactorial Trait
Heritability
2(Cmz - Cdz)
HIGH heritability
close to 1 = trait primarily determined by genetic factors
Low heritability
close to 0 = trait primarily determined by environmental factors
Pyloric Stenosis
5X more common in men (if in women incidence risk is higher)
Congenital Hip Dysplasia
9X more common in females
Common adulthood disease - complex interplay of genes and environment
a. CV disease
b. Cancer
c. Diabetes
d. Alzheimer’s
e. Obesity
f. Alcoholism
g. Psychiatric disorders
Genes involved in pyloric stenosis
NOS1, TRPC-1/5/6, MLN, MLNR
Environment involved in pyloric stenosis
posture, helicobacter infection
