Meiosis Flashcards
Prophase
chromosomes condense, kinetochore and MT assemble
Prometaphase
nuclear envelope breaks, MT binds kinetochore
Metaphase
chromatids align a metaphase plate
Anaphase
centromeres and kinetochores split, sister chromatids migrate to opposite poles
Telophase
MTs and kinetochore disassemble, nuclear envelope forms and chromatids decondense
Interphase
chromosomes duplicate
Prophase I
bivalents join and genetic recombination occurs
Metaphase I
Bivalents align at metaphase plate
Anaphase I
duplicated homologs separate (sister chromatids remain attached)
Telophase I
2 daughter cells result with haploid number of chromosomes, but diploid amount of DNA (1n, 2c)
Meiosis I
reductive division stage
Meiosis II
equational division
Nondisjunction at meiosis I
results in non-separated homologous chromosomes – too many of too few homologs in daughter cells
Nondisjunction at meiosis II
results in non-separated sister chromatids – too few or too many chromosomes in daughter cell
Synaptonemal complex
ladder-like protein scaffold with two lateral elements and a central element; between homologs
SYCP1
Central element
SYCP2 and SYCP3
Lateral elements
Mutations in SYCP1,SYCP2, and SYCP3
subfertility or infertility
Leptonema
DSBs by SPO11, Pairing of homologs, LE forms of SC
Zygonema
Synapsis, LE + CE of SC, and DSB begin repairing via non-cross-over and cross-over
Pachynema
SC and synapsis complete, ALL DSBs repaired, chiasmata (1/homolog at least)
Diplonema
SC breaks down, homologs separate except at chiasmata
SPO11
endonuclease that creates 200-400bp DSB non-randomally throughout genome
ALL DSBs are repaired by…
Pachynema of Prophase I