Multi-Systems II: Bugs and Drugs

Question 1

Tx: Actinomycosis

Answer 1

Penicillin G

Surgical Drainage of Abscesses

Question 2

Tx: Anthrax

Answer 2

Penicillin G

anti-PA vaccine

Question 3

Tx: Clostridium perfringens

Answer 3

Penicillin, Clindamycin (only in weak infections)

Surgical removal of Infected areas

Hyperbaric Oxygen to kill anaerobic organims

Question 4

Tx: Tetanus, Lockjaw

Answer 4

Penicillin, Metronidazole

Diazepam (a GABA agonist)

DTaP

Clean wound
Anti-toxin (Human anti-tetanospasmin immunoglobulin)

Question 5

Tx: Clostridium difficile

Answer 5

Metronidazole (Oral)
Vancomycin (Oral)

causative ABX (Clindamycin)

Question 6

Tx: Clostridium botulinum

Answer 6

Anti-Toxin

Respiratory Support

Question 7

Tx: Bacteroides fragilis

Answer 7

Metronidazole, Clindamycin

Sx Drain abscess + Repair lesions

Question 8

Tx: Yersinia pestis

Answer 8

Streptomycin, Tetracycline

Vaccine (killed and attenuated) against F1 antigen

Question 9

Tx: Cat Scratch Disease

Answer 9

Azithromycin, Doxycycline

Question 10

Tx: Tularemia

Answer 10

Streptomycin

Live-attenuated Vaccine for High-risk individuals

Question 11

Tx: Brucellosis

Answer 11

Doxycycline + Gentamicin

Prevention: Pasturization of Milk

Question 12

Tx: Pasteurella multocida

Answer 12

Penicillin G

Clean and Drain Wound

Question 13

Tx: Yellow Fever, Dengue Fever, etc.

Answer 13

Vaccine:
Yellow Fever - Live-attenuated vaccine
Japanese Encephalitis - Formalin-killed vaccine

Prevention: Mosquito control

Question 14

Tx: EEE, VEE, WEE

Answer 14

Vaccine: Formalin-inactivated or Attenuated virus

Killed vaccines for EEE and WEE

Question 15

Tx: Colorado Tick Virus

Answer 15

None Available

Question 16

Tx: Lassa Virus

Answer 16

Ribavirin

Serum from Convalescent Individuals (Severe cases)

Prevention: Rodent Control

Question 17

Tx: Hantavirus (Sin Nombre Virus)

Answer 17

Supportive

Question 18

Tx: Coronavirus

Answer 18

None Available

Question 19

Tx: Rabies Virus

Answer 19

HRIG (Human Rabies Immune Globulin) Antibodies (Passive)

Human Diploid Cell Vaccine (Live-attenuated)

Question 20

Tx: Ebola, Marburg Virus

Answer 20

None Available

Serum from Survivors

Question 21

Tx: Smallpox Virus

Answer 21

Cowpox vaccine

Vaccinia (Live-attenuated)

Question 22

Tx: Syphilis

Answer 22

Penicillin G

Question 23

Tx: Leptospira interrogans

Answer 23

Penicillin G

Prophylaxis: Doxycycline

Question 24

Tx: Lyme Disease

Answer 24

Doxycycline or Amoxicillin (Stage 1)

Ceftriaxone (Stage 2 and 3)

Question 25

Tx: Borrelia recurrentis

Answer 25

Penicillin, Tetracycline

Question 26

Tx: Typhus

Answer 26

Tetracycline, Chloamphenicol

Question 27

Tx: Q Fever

Answer 27

Tetracycline

Question 28

Tx: Rocky Mountain Spotted Fever

Answer 28

Doxycycline, Chloramphenicol

Question 29

Tx: Leishmaniasis, “Kala-Azar”

Answer 29

Stibogluconate Sodium (IV)

Miltefosine

Antimonials

Amphoteracin B

Question 30

Tx: Chagas’ Disease, American Trypanosomiasis

Answer 30

Acute: Nifurtimox, Benznidazole

Chronic: No Treatment

Question 31

Tx: Sleeping Sickness, African Trypanosomiasis

Answer 31

• T.b. gambiense
  
  • Early: Suramin, Pentamidine
  • Late (CNS): Efiornithine, nifurtimax
• T.b. rhodesiense
  
  • Early: Suramin
  • Late (CNS): Melarsoprol (related encephalopathy)

Question 32

Tx: River Blindness, Onchocerciasis

Answer 32

Ivermectin (only effective against microfilariae, not adults)

Sx removal of nodules