Multi-Organ Dysfunction Syndrome (MODS)

Question 1

Define MODS?

Answer 1

A clinical syndrome characterized by the development of progressive and potentially reversible physiologic dysfunction of 2 or more organs or organ systems that is induced by a variety of insults, including sepsis

Question 2

What does MODS usually result from?

Answer 2

Infection
Injury
Hypoperfusion
Hypermetabolism

Question 3

What is the aetiology of MODS?

Answer 3

The primary cause can trigger a systemic inflammatory response (sepsis or SIRS)
SIRS + infection –> severe sepsis –> MODS

Question 4

What is the epidemiology of MODS?

Answer 4

Not very common

Question 5

How are the presenting symptoms and Signs of MODS classified?

Answer 5

Multiple Organ Dysfunction Score

Question 6

What is Stage 1 of the Multiple Organ Dysfunction Score?

Answer 6

Increased volume requirements, mild respiratory alkalosis, oliguria, hyperglycaemia, increased insulin requirements

Question 7

What is Stage 2 of the Multiple Organ Dysfunction Score?

Answer 7

Tachypnoea, Hypocapnia, hypoxaemia, moderate liver dysfunction and haematologic abnormalities

Question 8

What is Stage 3 of the Multiple Organ Dysfunction Score?

Answer 8

Shock, azotaemia, acid-base disturbance, significant coagulation abnormalities

Question 9

What is azotaemia?

Answer 9

High nitrogen in the blood

Question 10

What is Stage 4 of the Multiple Organ Dysfunction Score?

Answer 10

Vasopressor dependent
Oliguria
Anuria
Development of Ischaemic Colitis and lactic acidosis

Question 11

What are the appropriate investigations for MODS?

Answer 11

Monitor Vital Signs

ABG may be necessary to look at hypoaemia, lactic acidosis etc.