Ischaemic Heart Disease Flashcards
Define Ischaemic Heart Disease?
Characterised by decreased blood supply to the heart muscle resulting in chest pain (angina pectoris)
What are the two ways Ischaemic Heart Disease can present?
Stable angina or Acute Coronary Syndrome (ACS)
How can ACS be further subdivided into?
Unstable angina
NSTEMI
STEMI
What is unstable angina?
Chest pain at rest due to ischaemic but without cardiac injury
What is STEMI?
ST elevation with transmural infarction
What is MI?
Cardiac muscle necrosis resulting from ischaemia
What is the epidemiology of ischaemic heart disease?
Common
Prevalence > 2%
More common in males
Annual incidence of MI in the UK ~ 5/1000
When does Angina Pectoris occur?
When myocardial oxygen demand exceeds oxygen supply
What is Angina Pectoris due to?
Atherosclerosis
What are the rarer causes of angina pectoris?
Include coronary artery spasm (e.g. induced by cocaine)
Arteritis
Emboli
What is the pathophysiology of atherosclerosis?
Endothelial injury leads to migration of monocytes into the subendothelial space
These monocytes differentiate into macrophages
Macrophages accumulate LDL lipids and become foam cells
These foam cells release growth factors that stimulate smooth muscle, proliferation, production of collagen and proteoglycans
This leads to the formation of an atherosclerotic plaque
What are the risk factors for Ischaemic Heart Disease?
Male Diabetes Mellitus Family History Hypertension Hyperlipidaemia Smoking
What are the presenting symptoms of ACS?
Acute-onset chest pain
Central, heavy, tight, crushing pain
Radiates to the arms, neck, jaw or epigastrium
Occurs at rest
More severe and frequent pain that previously occuring stable angina
What are the associated symptoms of ACS?
Breathlessness
Sweating
Nausea and vomiting
Silent Infacts occur in the elderly and diabetics
What are the presenting symptoms of Stable Angina?
Chest pain brought on by exertion and relieved by rest
What are the signs of ACS on physical examination?
Pale Sweating Restless Low-grade pyrexia Check both radial pulses to rule out aortic dissection Arrhythmias Disturbances of BP New heart murmus Signs of complications
What are signs of complications of ACS on physical examination?
Acute heart failure
Cardiogenic Shock
What is important to remember when physically examining for ACS?
There may be no clinical signs
What bloods would you do for Ischaemic Heart Disease?
FBC U&Es CRP Glucose Lipid profile Cardiac enzymes (troponins and CK-MB) Amylase (pancreatitis could mimic MI) TFTs AST and LDH (raised 24 and 48 hours post-MI, respectively)
What do we see on an ECG for unstable Angina or NSTEMI?
May show ST depression or T wave inversion
What would we see on an ECG with STEMI?
Hyperacute T waves
ST elevation (> 1 mm in limb leads, > 2 mm in chest leads)
New-onset LBBB
Later changes: T wave inversion and Pathological Q waves
What is the relationship between ECG leads and the side of the heart?
Inferior: II, III, aVF
Anterior: V1-V5/6
Lateral: I, aVL, V5/6
Posterior: Tall R wave and ST depression in V1-3
How do we use CXR in ischaemic heart disease investigations?
Check for signs of heart failure
What are the indications for an Exercise ECG in Ischaemic Heart Disease?
Patient with troponin-negative ACS or stable angina with a high pretest probability of coronary heart disease
Pretest probability is based on characteristics of chest pain, cardiac risk factors, age and gender
Digoxin is associated with giving a false-positive result