Muller's morphs Flashcards
How are mutations classified in Muller’s morphs?
Based on the effect on gene product function or activity
What is a compound heterozygote?
A individual who has two different mutant alleles of a gene
What is the Df allele?
Deficient. The gene is deleted
What are the 5 Muller’s morphs?
Amorph, hypomorph, hypermorph, antimorph, and neomorph
How much gene product activity is seen in an amorph (compared to WT) when:
a) WT/m
b) m/m
c) m/Df
a) Same as the WT if the null allele is recessive. No function if it is dominant
b) No function
c) No function
How much gene product activity is seen in a hypomorph (compared to WT) when:
a) WT/m
b) m/m
c) m/Df
a) Same as WT if recessive, less than WT if dominant
b) Less than WT
c) Way less than WT, but still has a bit of function
How much gene product activity is seen in a hypermorph (compared to WT) when:
a) WT/m
b) m/m
c) m/Df
a) More than WT
b) A lot more than WT
c) less than with 2 copies of the mutant allele, might be close to the WT phenotype
What is a amorphic allele?
An allele that encodes a gene product with no function
Are amorphic mutations a gain of function or a loss of function?
Loss of function
Are amorphic mutations dominant or recessive?
Usually recessive, but sometimes dominant
What is a hypomorphic allele?
An allele whose gene product still has some function, but less function than the WT gene product
Are hypomorphic mutations a gain of function or a loss of function?
Loss of function
Are hypomorphic mutations dominant or recessive?
Usually recessive, but sometimes dominant
How can we tell an amorph and a hypomorph apart?
Homozygous mutant and deficient will have the same phenotype if it is an amorph. They will be different if it’s a hypomorph, which the deficient being more severe
What happens to the phenotype if more copies of an amophic allele are added?
Nothing. The alleles have no function