Mucosal Immunity

Question 1

largets deposit of lymphos?

Answer 1

mucosa

Question 2

do B cells get to epithelium?

Answer 2

yes

Question 3

MALT

Answer 3

largest lymph tiss.

60-70% of all lymphos

has subdivisions

Question 4

PP

Answer 4

peyers patch

sample antigens through M-cells

Question 5

ILF

Answer 5

clusters of lymphocytes located throughout the length of small intestine

omstly B cells

act as inductive sites for Mucosal immune responses

Question 6

CPs

Answer 6

cryptopatches

could be a site of intraepithelial T lymph development.

may be precursors to ILFs

Question 7

IEC, Enterocyte

Answer 7

AKA absorptive epi cells

most intestinal epithelia is made up of these cells, covered in mucus and glyccalix

Question 8

goblet cell

Answer 8

secretes mucins: heavily glycosylated proteins. 2 types.

surface and secreted.

Question 9

paneth cells

Answer 9

make antimicrobial peptides: a-defensins, cause cell wall rupture.

Question 10

M cell

Answer 10

microfold cell, specialized epi cell.

no villi, folded BM, dont secrete mucus or enzymes, lack a surface glycocalix.

expose themselves to gut environment, take up antigen.

Question 11

pathogenic exploitation of Mcells

Answer 11

salmonella kills them. polio and retros are taken in through transcytosis as well

Question 12

how many IEL per epithelial cells

Answer 12

1 for every ten

Question 13

IEL traits

Answer 13

limited TCR diversity.

have specific receptor for binding E-cadherin

mostly CD8, activated phenotype. (primed)

Question 14

IgA

Answer 14

can be transported through the lumen both ways.

Question 15

what are the 4 ways antigen gets presented to Tcells?

Answer 15

.

Question 16

what are the two APs in the gut?

Answer 16

Effector- CX3CR1+, stimulate protective effector Tcell responses

Regulatory- CD103+, stimulate regulatory Tcell responses. immunity suppression.

Question 17

retinoic acid

Answer 17

secreted by DCs to activate regulatory T cells.

naive t cells receive it and go through foxP3

Question 18

polarization of TLRs

Answer 18

this helps keep regulation and effect in balance.

can be on baso and luminal sides.

ex. TLR 9 on both sides, in the lumen it inhibits NFkB, on the baso side it activates it.

Question 19

how does a mucosa activated lympho find its way back to the gut?

Answer 19

integrins and chemokines!

they mediate the trafficking.

Question 20

IgA defficiency

Answer 20

compensated by IgM, but still more susceptible.

Question 21

think about tolerance vs immunity.

think about anatomical specialized functions

think about special IgA

Answer 21

.