Hypersensitivity

Question 1

Type 1

Answer 1

IgE mediated
A: Soluble antigen
M: Mast cell activation
E: Allergies, asthma

Question 2

Type 2

Answer 2

IgG mediated
A: Cell or matrix associated antigen, cell surface receptor
M: complement, FcR+ cells, phags, NKs. antibody altered signaling
E: drug allergies, chronic urticaria

Question 3

Type 3

Answer 3

IgG mediated
Soluble antigen
complement, phags
serum sickness, arthus reaction

Question 4

Type 4 Th1

Answer 4

Th1 mediated
soluble antigen
Macro activation
Contact dermatitis, tuberculin rxn

Question 5

Type 4 Th2

Answer 5

Th2 mediated
soluble antigen
Eosinophil activation
chronic asthma, chronic allergies

Question 6

Type 4 CTL

Answer 6

cell-assciated antigen
cytotoxicity
contact dermatitis

Question 7

Universal Donor

Answer 7

O-type

Question 8

universal recipient

Answer 8

AB-type

Question 9

how many IgGs does it take to fix complement?

Answer 9

2!!!!!! IgM can do it with just one.

Question 10

Arthus reaction

Answer 10

similar to wheal and flare

involves the in situ formation of antigen/antibody complexes after the intradermal injection of an antigen. If the animal/patient was previously sensitized, it occurs.

Question 11

pathologies of Type 3 reactions

Answer 11

IV: vasculitis, nephritis, arthritis
SubCu: arthus rxn
Inhaled: farmer’s lung

Question 12

delayed type sensitivity

Answer 12

antigen: proteins, insect venom, mycobacterial proteins.
consequence: local skin swelling, erythema, induration, cellular.

CYTOKINES
Cell mediated

Question 13

Type 4 Th1

Answer 13

Th1 mediated
soluble antigen
Macro activation
Contact dermatitis, tuberculin rxn

DELAYED!

Question 14

Type 4 CTL

Answer 14

cell-assciated antigen
cytotoxicity
contact dermatitis

Question 15

contact hypersensitivity

Answer 15

A: pentadecacatechol, DNFB, smal metal ions(ALE)

Con: memory response. two ways:
presented to MHC II and MHC I

Question 16

Celiac’s

Answer 16

changes due to Lymph infiltration, inflammation and activated macros.

Gluten sensitive enteropathy

Question 17

pathologies of Type 3 reactions

Answer 17

IV: vasculitis, nephritis, arthritis
SubCu: arthus rxn
Inhaled: farmer’s lung

Question 18

delayed type sensitivity

Answer 18

antigen: proteins, insect venom, mycobacterial proteins.
consequence: local skin swelling, erythema, induration, cellular.

CYTOKINES

Question 19

contact hypersensitivity

Answer 19

haptens: poison ivy.
Small metal ions: nickel, chromate

local epidermal rxn: erythema, cell infiltrate, vesicles, vesicles, intraepidermal abcesses

Question 20

Gluten-sensitive enteropathy (celiac)

Answer 20

A: gliadin
Con: villous atrophy in small bowel, malabsorption

Question 21

contact hypersensitivity

Answer 21

pentadecacatechol

memory response. two ways:
presented to MHC II and MHC I

Question 22

Celiac’s

Answer 22

changes due to Lymph infiltration, inflammation and activated macros.

Question 23

Celiac’s

Answer 23

changes due to Lymph infiltration, inflammation and activated macros.

Question 24

Botulism

Answer 24

Descending, flaccid paralysis.

Question 25

immune complex disease

Answer 25

Type 3 sensitivity, associated with serum antibody.

7-10 days after exposure.
chills, rash, arthritis, vasculitis, glomerulonephritis.

Question 26

cytokines

Answer 26

products of type-4 responses.

chemokines: macro recruitment
IFN-y: activates macros
TNF-a and LT: local tissue destruction
IL-3/GM-CSF: monocyte production