Hypersensitivity Flashcards
Type 1
IgE mediated
A: Soluble antigen
M: Mast cell activation
E: Allergies, asthma
Type 2
IgG mediated
A: Cell or matrix associated antigen, cell surface receptor
M: complement, FcR+ cells, phags, NKs. antibody altered signaling
E: drug allergies, chronic urticaria
Type 3
IgG mediated
Soluble antigen
complement, phags
serum sickness, arthus reaction
Type 4 Th1
Th1 mediated
soluble antigen
Macro activation
Contact dermatitis, tuberculin rxn
Type 4 Th2
Th2 mediated
soluble antigen
Eosinophil activation
chronic asthma, chronic allergies
Type 4 CTL
cell-assciated antigen
cytotoxicity
contact dermatitis
Universal Donor
O-type
universal recipient
AB-type
how many IgGs does it take to fix complement?
2!!!!!! IgM can do it with just one.
Arthus reaction
similar to wheal and flare
involves the in situ formation of antigen/antibody complexes after the intradermal injection of an antigen. If the animal/patient was previously sensitized, it occurs.
pathologies of Type 3 reactions
IV: vasculitis, nephritis, arthritis
SubCu: arthus rxn
Inhaled: farmer’s lung
delayed type sensitivity
antigen: proteins, insect venom, mycobacterial proteins.
consequence: local skin swelling, erythema, induration, cellular.
CYTOKINES
Cell mediated
Type 4 Th1
Th1 mediated
soluble antigen
Macro activation
Contact dermatitis, tuberculin rxn
DELAYED!
Type 4 CTL
cell-assciated antigen
cytotoxicity
contact dermatitis
contact hypersensitivity
A: pentadecacatechol, DNFB, smal metal ions(ALE)
Con: memory response. two ways:
presented to MHC II and MHC I
Celiac’s
changes due to Lymph infiltration, inflammation and activated macros.
Gluten sensitive enteropathy
pathologies of Type 3 reactions
IV: vasculitis, nephritis, arthritis
SubCu: arthus rxn
Inhaled: farmer’s lung
delayed type sensitivity
antigen: proteins, insect venom, mycobacterial proteins.
consequence: local skin swelling, erythema, induration, cellular.
CYTOKINES
contact hypersensitivity
haptens: poison ivy.
Small metal ions: nickel, chromate
local epidermal rxn: erythema, cell infiltrate, vesicles, vesicles, intraepidermal abcesses
Gluten-sensitive enteropathy (celiac)
A: gliadin
Con: villous atrophy in small bowel, malabsorption
contact hypersensitivity
pentadecacatechol
memory response. two ways:
presented to MHC II and MHC I
Celiac’s
changes due to Lymph infiltration, inflammation and activated macros.
Celiac’s
changes due to Lymph infiltration, inflammation and activated macros.
Botulism
Descending, flaccid paralysis.
immune complex disease
Type 3 sensitivity, associated with serum antibody.
7-10 days after exposure.
chills, rash, arthritis, vasculitis, glomerulonephritis.
cytokines
products of type-4 responses.
chemokines: macro recruitment
IFN-y: activates macros
TNF-a and LT: local tissue destruction
IL-3/GM-CSF: monocyte production
