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Oral Histology > Mucosa > Flashcards

Mucosa Flashcards

1
Q

The 2 cell lines of basal cells

A

2 types of population A. Serrated o has protoplaimc pedicles projecting into the CT
o Healvly packed with tonofimament
o Adapted for attachment
B. Non-serrated o Stem cells (slowy cycling cells)

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2
Q

Basal cells general features

A

§ Single layer of cub. Cells § Least diffrentiated § Promenant mitotic activity which give rise to ü stem cells go through the cells cycle slowly and produce basal cells
ü Amplyfing cells which increase the number of cells avialable for maturation
§ Active Pr. Synthesis cells ü Tonofilaments aggregate to form tonofiblriles
ü Protein of the basal lamine

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3
Q

stratum germinativum

A

Deep layers (para-basal layer) can divide and share the same function with the basal cell layer, together they are called

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4
Q

keratinosome

A

Odland body

lamellar granule

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5
Q

Odland body composition

A

ü Rich in glycolipids

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6
Q

Granular cells features

A

Cells are..
o Flatter, Wider, larger & with less organelles o More maturation o Contains more tonofilaments o The nuclei show signs of degeneration & pyknosis.
§ Reduced rates of Pr. Synthesis. Prs such as involucrin & loricrin help to increase the thickness of the cell membrane and forming a resistant cornified cell envelope

Keratohyaline granules ü basophilic granules ü Contains pro-filaggrin
(precursor of the protein filaggrin) which plays an important role in binding keratin filaments together
o Odland body also present in this layer and discharge their content in the intercellular spaces

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7
Q

Para k

Organelles

A

Cells retain the pyknotic or shrunken nuclei or partially lysed organelles

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8
Q

Results of high turnover of mucosa

A

Ø Healing of the oral mucsa is faster than healing of the skin Ø Oral ulcers re-epthilialized within 12-15 days Ø Oral wounds heal without scar formation

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9
Q

Turnover rate of mucosa

A

Keratnized mucosa 40-55 days o Non- keratnized mucosa 25 days

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10
Q

Dodf between k and non k

A
  • no granular cell
  • no kerato hyaline granules
  • no filaggerin
  • smaller membrane coated granules
  • tono filaments are less developed
  • basal cell is the same
  • intermediate cells are larger
    Closely packed less prominent junctions
  • superficial layer contain more organelles and a nucleus
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11
Q

Melanocytes

A

Long, living cells, selfreplicating

Contact with 30–40 keratinocytes

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12
Q

Langerhan cell

A

Under the influence of chemokines by the keratinocytes

Present In the upper layer of oral epithelium

E\m vacuolated nucleus

Has a characteristic rod- or flask-shaped granules

Peptides are transferred and presented to the tlymphocytes either in the lamina propria or at the regional lymph nodes

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13
Q

Merkel cell

A

Derived from the neural crest

Contains Keratin filaments &desmosomes

Do not appear as clear cells

Nucleus shows deep invagination (rodlet appearance)

Most seen in masticatory mucosa

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14
Q

Lymphocyte

A

Closely associated with the
langerhans cells

Transient, present only in case of inflammation
do not reproduce themselves in epithelium

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15
Q

Basement membrane

A

oIt is 1 to 4 µm thick and it includes the reticular fibers & anchoring fibers
o it is relatively cell free. oThis zone stains positively with the
periodic acid-schiff (pas) method Ø Indicating that it contains neutral mucopolysaccharides (glycosaminoglycans).

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16
Q

Lamina densa and lucida

A

Made up of A. clear zone (lamina lucida) Ø20–40 nm wide glycoprotein layer Ø contains type IV collagen
B. dark zone (lamina densa)
Ø contain laminin and bullous pemphigoid antigen

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17
Q

Additional one function if BM

A

promote differentiation, peripheral nerve regeneration and growth

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18
Q

Ratios of fibers of lamina propria

A

Collagen type 1 90%
Type 3 8%
With elastic fibers

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19
Q

Function of rougea area

A

It plays a part in speech o During denture processing it function as secondary stress bearing area
o In fronsic dentistry, it can be used to idinitfy individulas as it is unique like fingure prints

20
Q

Muco ging line in palate?

A

• On the palate, there is no sharp distinction between the gingiva and the peripheral palatal mucosa

21
Q

type of K of gingiva

A

q Para-keratinized 75% q Ortho- keratinized 15% q Non-keratinized 10%

22
Q

Free ging width

A

0.5 to 1.5

23
Q

Sulcus depth in various occasions

A

It is under absolute normal conditions or Germfree animals, its depth is about 0 mm
• In normal healthy individuals, the depth of gingival sulcus is 1.8 to 2 mm.

24
Q

Inflammatory cells and sulcular epithelium

A

It is lined by non- keratinized epithelium that permit some inflammatory cells

25
Q

Attached gingival width

A

Width of the attached gingiva in incisors region is 3.5-4.5mm & in the premolar region is 1.9 mm

26
Q

Attached ging is wider in …

A

ü The width of attached gingiva increase with age and in super-erupted teeth

27
Q

Factors affecting stippling

A
  • More buccal than lingual
  • more in males
  • absent in infants and old age
  • inflammation
28
Q

Terminology of parts of interdental gingiva

A

The depression in gingiva forms vertical folds called interdental grooves
o Col In between the buccal and lingual peaks of interdental gingiva

29
Q

Incision in musticatory mucosa?

A

Incisional wound doesn’t create gap

30
Q

Vestibular mucosa

A

The mucosa of the vestibule is thin, non-keratinized
o Loosely textured allowing free movement of the cheek and lips.
o Median and lateral labial fermium are folds of mucous membrane contains C.T without muscles fibers

31
Q

Taste buds number in fungiform

A

1to3

32
Q

N. of circumvallate papilla

A

8 to 12

33
Q

Inner supporting cells of taste buds

A

Inner supporting cells are shorter ones are spindle shaped.

34
Q

Number and shape of receptor cell

A

4-20 cells.. receptors of taste stimuli
Cells are darker & more slender but thickened at middle Hair like process extend into the gustatory pore without reaching its outlet

35
Q

Zones of lip

A

Skin
Vermilion zone
Intermediate zone
Labial mucosa

36
Q

Definition of suckling pad

A

In infants the intermediate zone is thickened and

appears white, which represents an adaptation to suckling called the suckling pad.

37
Q

Vermilion border age change

A

In young people this border is demarcated sharply, but as a person is exposed to ultraviolet radiation, the border becomes diffuse and poorly defined.

38
Q

Mucogingival junction clinical identification

A

This junction is identified clinically by Ø A slight indentation called the mucogingival

39
Q

Junctional epi histology

A

Ø Epithelium.. q Nonk. St. sq. epith. q Basal cell layer I. Single layer of cuboidal cells II. Attached to each other by desmosomes & to the basal lamina by hemi-desmosomes.
q Supra-basal and superficial cells a) Polyhedral and become spindle or flattened at the tooth surface.
b) Obliquely directed to reach tooth surface parallel to it.
c) The cells form 3-4 layers apically and increased to 15-30 layers coronally.
d) Prominent intercellular spaces.

Ø Basal lamina.. q External basal lamina i. Regular basal lamina formed of lamina lucida and lamina densa.
ii. Interface the lamina propria of the gingiva iii. Basal cell layer resting on the external basal lamina
q Internal basal lamina i. Binds to hard tissue ii. Supra-basal cells resting on the internal basal lamina
iii. It attachs the gingiva to the tooth
Ø Lamina propria.. q Less collagen fibers q Contains inflammatory cells.

40
Q

Properties of j.e cells

A

-high turn over rate 2to 6 days
-rapid division
- large inter cellular spaces
Contain macrophages lymphocytes and plasma cells
-Less desmosomes and tonofilaments
- no rete pegs
- large cytoplasm with prominent golgi and rer

41
Q

Zones of j.e

A

Junctional epithelium is divided into three zones

  1. Coronal zone is highly semipermeable and allows entry of toxins and passage of gingival fluid into the sulcus.
  2. Middle zone is an adhesive zone (Attachment epithelium).
  3. Apical zone has a proliferative capacity to replace shaded cells of the junctional epithelium.
42
Q

Integrity of the dento-gingival junction

function

A
  1. Acts as a barrier against plaque bacteria
  2. Allow the following to gain access to the gingival margin o Gingival fluids o Inflammatory cells o Immune host defense
  3. High rate of turn over o Fast repair
43
Q

Primary and secondary attachment epi

A

and once the tip of crown erupt the REE is called primary attachment epith

When the REE has disappeared, the primary attachment epithelium is replaced by a secondary attachment epithelium

44
Q

Features of stage 3 of djg shift

A

q This is not a passive manifestation. The epithelium keeps shifting along tooth surface, and no longer remains at the CEJ
q This is a slow and not a continuous process, which is an effort by the body to maintain the integrity of the dento-gingival junction

45
Q

Time frame of stage 1 and 2

A

1—- up till final year of primary teeth life and for permanent in 20 to 30 y

2—- 40 years

3— non continuous but slow process of shift for maintaining integrity of epi.j

4 —- pathological

46
Q

Clinical age changes

A
  • less saliva
  • vermilion border less distinct
  • cracking in commissure
  • loss of tongue papilla
  • loss of stippling
  • lingual varicose
  • decrease ability to repair
47
Q

Histologoical changes

A

oDecreased Number & thickness of rete ridges oDecreased Mitotic activity oDecreased Degree of keratinization oDecreased Resiliency

qTurnover gets longer q Thickening of collagen bundles

Oral Histology (12 decks)

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