MTB

Question 1

Extensively drug resistant Tan

Answer 1

Resistant to fluroquinolone and >1 first line anti TB injectable drug (Capreomycin, Kanamycin, Amikacin)

Question 2

What is category I in TB

Rx

Answer 2

PTB
Ectrepulmonary Tb except bone and CNS

Rx 2HRZE/4HR

If extrapulmonary Tb bones and clear breath sounds 2 HRZE/10 HR

Question 3

Define PRESUMPTIVE TB (replaced TB symptomatic/TB suspect)

Answer 3

15 years old
Cough at least 2 weeks duration; unexplained cough of any duration or
CXR findings suggestive of PTB with or without symptoms

Question 4

Paradoxical response to TB treatment

Answer 4

Continue

Treat sympyomatically

Question 5

RF for InH associated neuropathy

Answer 5

Alcoholism
Malnutrition
Diabetes 
Co infection with HIV
Slow acetylator
Pregnancy
Breast feeding
Renal failure

Question 6

Rx treatment relapse TB CNS bones joints

Answer 6

2 HRZES
1 HRZE
5 HRE

Monitor 3,5,8

Question 7

When to stop TB treatment increasing ALT

Answer 7

ALT> 3x with symptoms
ALT >5x no symotoms
Re introduce meds after ALT <2x ULN

R with or without E
H
Z- never reintroduced

Question 8

Rx PZA associated gouty arthritis (not hyperuricemia)

Answer 8

Stop PZA

Administer standard treatment for hyperuricemia/gout

Question 9

When are Tb patients considered non infectious

Answer 9

14 daily doses of treatment for bacteriooogically confirmed TB

5 daily doses of treatment for clinically diagnosed Tb

Question 10

When to use corticosteroids In TB

Answer 10

TB meningitis

TB pericarditis

Question 11

TB meningitis corticosteroids dose

Answer 11

Dexamethasone 0.4 mg/kg/24 h reduce course over 6-8 weeks

Question 12

TB pericarditis steroid dose

Answer 12

Prednisolone 60 mg for first 4 weeks
30 mg weeks 5-8
15 mg weeks 9-10
5 mg week 11

Question 13

Treatment of TB in patients with chronic liver disease

Answer 13

2 HRES/ 6HR
9HRE or
2 HEs/ 10 HE

Question 14

Treatment course of drug resistant TB

Answer 14

18 months