COPD

Question 1

Contributes to airway fibrosis in COPD

Answer 1

TGF B

Question 2

Major physiologic change in COPD

Answer 2

Airflow limitation

Question 3

In response to cigarette smoke CD8 cells are recruited where they increase ______

Answer 3

MMP 12 (macrophage elastase)

Question 4

Most potent secretagoguenidentified

Answer 4

Neutrophil elastase

Question 5

Emphysema in cigarette smoking most commonly affects

Answer 5

Upper lobes and superior segments of the lower lobes

Centriacinar

Question 6

PaO2 in COPD is normal until FEV of _____ is reached

Answer 6

50%

Question 7

PaCO2 in COPD increases when FEV of ______ is reached

Answer 7

FEV <25

Question 8

Major gas abnormality in COPD

Answer 8

V/Q mismatch (due to low paO2)

Question 9

What are the diff alleles of a2 antitripsin dgiciency

Answer 9

M allele normal
S allele slightly reduced
Z allele markedly reduced

Question 10

What is HOOVER’s sign?

Answer 10

Paradoxical inward movement of ribcage with inspiration

Question 11

The current definitive test for establishing the presence or absence of emphysema in living subjects

Answer 11

CT scan