MSRA: Primary Biliary Cirrhosis

Question 1

Which antibodies are involved in primary biliary cirrhosis?

Answer 1

Anti-mitochondrial antibodies (M2 subtype)

Also have raised IgM levels

Question 2

Which conditions are associated with primary biliary cirrhosis?

Answer 2

Sjogren’s syndrome
Thyroid disease
Systemic sclerosis

Question 3

Patients with primary biliary cirrhosis are at increased risk of which cancer?

Answer 3

Hepatocellular carcinoma

Question 4

What is the treatment of PBC?

Answer 4

Urso

Question 5

What are the features of PBC?

Answer 5

Middle aged woman
Sjogren’s/dry mouth
Pruritis and jaundice