MSRA haematology and oncology

Question 1

Oestrogen positive breast cancers can be treated with what agents?

Answer 1

Anastrazole
Tamoxifen

Question 2

Tamoxifen is used in pre or post menopausal women?

Answer 2

Premenopausal women

Question 3

what is the most common type of oesophageal cancer?

Answer 3

Adenocarcinoma

Question 4

which type of oesophageal cancers are commonly found in the upper 2/3 of the oesophagus ?

Answer 4

squamous cell carcinoma

Question 5

Von willibrands disease will cause what abnormality on the clotting screen?

Answer 5

Mildly prolonged APTT
Normal PT

Question 6

how is von willebrands disease inherited?F

Answer 6

autosomal dominant

Question 7

Von willebrand factor is a carrier for what clotting factor?

Answer 7

Factor VIII

Question 8

what is the most common inherited thrombophilia?

Answer 8

Factor V Leiden (activated protein C resistance)

Question 9

polycythaemia vera is a result of what mutation

Answer 9

JAK2

Question 10

what is the best investigation for pancreatic ca?

Answer 10

High res CT

Question 11

BRCA2 mutation is associated with risk of what cancer in men?

Answer 11

prostate

Question 12

which BRCA gene holds the highest risk of ovarian cancer?

Answer 12

BRCA 1 - 55%
BRCA 2 - 25%

Question 13

what blood test is raised in thalassaemia?

Answer 13

HbA2

Question 14

how is haemochromatosis inherited?

Answer 14

autosomal recessive

Question 15

which blood product carries the greatest risk of bacterial contamination compared with other types of blood products?

Answer 15

Platelet transfusion

Question 16

what feature is seen on blood film in patients with DIC?

Answer 16

Schistocytes

Question 17

urgent Upper GI endoscopy should be arranged for patients aged 55 with weight loss and what of the following features?

Answer 17

One of:
- upper abdominal pain
- reflux
- dyspepsia

Question 18

what are considered B symptoms in hodgkins lymphoma?

Answer 18

Weight loss >10% in 6 M
Fever > 38 degrees
Night sweats