MSK Tests/Signs Flashcards
Dermatomyositis
humeral attack of muscle capilaries and small arterioles - infarctions / proximal muscle weakness
- Gottron’s papules
- Anti-Mi2 & Anti-MDA5
- muscle biopsy
- Rx:
- corticosteroids
- Methotrexate
Polymyositis
T-cell mediated cytotoxic process against muscle antigens
proximal muscle weakness
- Anti-Jo-1
- elevated CK
- muscle biopsy
- Rx
- corticosteroids
- Methotrexate
Fibromyalgia
- no specific tests - test for other causes of symptoms
- Rx
- symtom specific
- pain: analgesics
- acetaminophen
- Tramadol
- muscle relaxants
- Cyclobenzaprine (Flexeril)
- anxiety
- Alprazolam (Xanax)
- insomnia
- Zolpidem (Ambien)
- antidepressants
- Duloxetine (Cymbalta), Venlafaxine (Effexor)
- pain: analgesics
- symtom specific
Chronic Fatigue Syndrome
- no specific test - r/o other causes
Complex Regional Pain Syndrome
follows surgery or trauma
- pain out of proportion
- skin color changes, dryness, shiny, wrinkled
- Rx
- NSAIDs, corticosteroids
- sympathetic nerve block
- PT/OT
- surgery
Marfan Syndrome
autosomal dominant connective tissue disorder
- treat pathology
Ehlers-Danlos Syndrome
heterogeneous disorder of connective tissue affecting collagen - joint hypermobility
- treat manifestations
- B-blocker to protect vessels
Osteogenesis Imperfecta
hereditary defects in bony matrix
- blue sclara
- bony deformities
- Rx
- Risedronate (increases bone density)
Systemic Lupus Erythematous
(SLE)
multisystemic inflammatory autoimmune disease
- non-erosive peripheral joint pain/stiffness out of proportion
- Anti-Smith autoantibody
- Anti-dsDNA
- Rx
- antimalarials
- Hydroxychloroquine
- NSAIDs, corticosteroids
- supplement Ca & Vit D w/ long term steroid
- DMARDs (immunosuppressants)
- Methotrexate (Trexall) - arthritis
- Cyclophosphamide - CNS
- Azathioprine (Imuran) - nephritis
- Mycophenolate (Cellcept) - nephritis
- IV immunoglobulin for flare-ups
- antimalarials
Sjorgren’s Syndrome
autoimmune attack of exocrine glands
- SICCA
- xerophthalmia (keratoconjunctivitis), xerostomia (mouth)
- Anti-SS-A (Ro) -or- Anti-SS-B (La)
- Rx
- fluids, lotion, humidifiers, good oral hygiene, annual eye/dental exams
Polymyalgia Rheumatica
inflammatory condition of shoulders and pelvic girdle
- sudden onset morning stiffness >45 min
- ASSOCIATED w/ GIANT CELL arteritis
- temporal artery biopsy (gold standard)
- Rx
- Prednisone
- Ca/Vit D
Polyarteritis Nodosa
necrotizing inflammation of vessels at branches/bifurcatons
- Livido reticularis
- Rx
- Prednisone
- Methotrexate
- Anti-viral if Hep B
- treat HTN

tumor prefixes
- osteo-
- chondro-
- fibro-
- radiolucent
- osteo - bone forming
- osteoid osteoma
- osteoblastoma
- osteoma
- chondro - cartilage forming
- chondroma
- osteochondroma
- chondroblasoma
- fibro - fibrous bone lesions
- fibrous dysplasia
- nonossifying fibroma
- radiolucent
- giant cell tumor
- unicameral bone cyst
- aneurysmal bone cyst
Osteoid Osteoma
benign ostoid forming tumor
- night pain
- <1cm cherry red lytic nidus
- Rx
- NSAIDs
- curettage/burring
- radiofrequency ablation

Osteoblastoma
large osteoid osteoma
- >2cm and more aggressive
- night pain
- nidus not visible on x-rays
- Rx
- NOT responsive to NSAIDs
- biopsy
- curettage and bone grafting
- tumor excision w/ bone reconstruction -or- internal fixation

Osteoma
benign deposit of new bone
- associated w/ Gardner’s syndrome (colonic polyps)
- firm w/ no pain
- typically on skull, tibia, femur
- Rx
- observation vs. marginal resection

Encondroma
benign cartilage formation in medullary canal
- associated with:
- Ollier’s disease
- Maffucci’s syndrome (+hemangiomas)
- “scalloped”/thinning on x-ray
- Rx
- no tx if asymptomatic
- biopsy
- curettage w/ bone grafting

Periosteal Chondroma
benign hyaline cartilage formation on surface of bone
- painful, sometime palpable mass
- saucerization w/ sclerosis on x-ray
- Rx
- excision
- need to r/o condrosarcoma

Osteochondroma
exostosis - growth on bone surface covered w/ benign cartilaginous cap
- pedunculated vs. sessile stalk
- Rx
- asymptomatic - monitor
- surgical excision

Chondroblasoma
cartilage forming tumor in epiphysis
- radiographic finding - well circumscribed/defined lytic lesion
- histology: “chickenwire calcification”
- Rx
- curettage and bone graft

Nonossifying Fibroma
(NOFs)
proliferation of fibrous tissue / fibrous cortical defect
- children/adolescents
- Jaffe-Campanacci Syndrome: multiple NOFs and cafe au lait spots
- Rx
- observation vs. curettage w/ bone graft

Fibrous Dysplasia
abnormal tissue formation in place of lamellar bone
- pain
- “ground glass” appearance on x-ray
- Rx
- surgery - rigid fixation
- Bisphosphates

Giant Cell Tumor
aggressive benign proliferation of multinucleated giant cells
- pain, swelling, deformity - can met to lungs
- lucent and ecentrically located, bony destruction/cortical breakthrough on x-ray
- Rx
- curettage, ablation, bone grafting, fixation

Unicameral Bone Cyst
fluid filled cyst w/ fibrous lining
- usually incidental finding or mild pain/swelling/stiffness
- Rx
- r/o sarcoma
- interlesion aspiration w/ corticosteroid injection
- curettage and bone graft









































































