MSK Tests/Signs Flashcards
Dermatomyositis
humeral attack of muscle capilaries and small arterioles - infarctions / proximal muscle weakness
- Gottron’s papules
- Anti-Mi2 & Anti-MDA5
- muscle biopsy
- Rx:
- corticosteroids
- Methotrexate
Polymyositis
T-cell mediated cytotoxic process against muscle antigens
proximal muscle weakness
- Anti-Jo-1
- elevated CK
- muscle biopsy
- Rx
- corticosteroids
- Methotrexate
Fibromyalgia
- no specific tests - test for other causes of symptoms
- Rx
- symtom specific
- pain: analgesics
- acetaminophen
- Tramadol
- muscle relaxants
- Cyclobenzaprine (Flexeril)
- anxiety
- Alprazolam (Xanax)
- insomnia
- Zolpidem (Ambien)
- antidepressants
- Duloxetine (Cymbalta), Venlafaxine (Effexor)
- pain: analgesics
- symtom specific
Chronic Fatigue Syndrome
- no specific test - r/o other causes
Complex Regional Pain Syndrome
follows surgery or trauma
- pain out of proportion
- skin color changes, dryness, shiny, wrinkled
- Rx
- NSAIDs, corticosteroids
- sympathetic nerve block
- PT/OT
- surgery
Marfan Syndrome
autosomal dominant connective tissue disorder
- treat pathology
Ehlers-Danlos Syndrome
heterogeneous disorder of connective tissue affecting collagen - joint hypermobility
- treat manifestations
- B-blocker to protect vessels
Osteogenesis Imperfecta
hereditary defects in bony matrix
- blue sclara
- bony deformities
- Rx
- Risedronate (increases bone density)
Systemic Lupus Erythematous
(SLE)
multisystemic inflammatory autoimmune disease
- non-erosive peripheral joint pain/stiffness out of proportion
- Anti-Smith autoantibody
- Anti-dsDNA
- Rx
- antimalarials
- Hydroxychloroquine
- NSAIDs, corticosteroids
- supplement Ca & Vit D w/ long term steroid
- DMARDs (immunosuppressants)
- Methotrexate (Trexall) - arthritis
- Cyclophosphamide - CNS
- Azathioprine (Imuran) - nephritis
- Mycophenolate (Cellcept) - nephritis
- IV immunoglobulin for flare-ups
- antimalarials
Sjorgren’s Syndrome
autoimmune attack of exocrine glands
- SICCA
- xerophthalmia (keratoconjunctivitis), xerostomia (mouth)
- Anti-SS-A (Ro) -or- Anti-SS-B (La)
- Rx
- fluids, lotion, humidifiers, good oral hygiene, annual eye/dental exams
Polymyalgia Rheumatica
inflammatory condition of shoulders and pelvic girdle
- sudden onset morning stiffness >45 min
- ASSOCIATED w/ GIANT CELL arteritis
- temporal artery biopsy (gold standard)
- Rx
- Prednisone
- Ca/Vit D
Polyarteritis Nodosa
necrotizing inflammation of vessels at branches/bifurcatons
- Livido reticularis
- Rx
- Prednisone
- Methotrexate
- Anti-viral if Hep B
- treat HTN
tumor prefixes
- osteo-
- chondro-
- fibro-
- radiolucent
- osteo - bone forming
- osteoid osteoma
- osteoblastoma
- osteoma
- chondro - cartilage forming
- chondroma
- osteochondroma
- chondroblasoma
- fibro - fibrous bone lesions
- fibrous dysplasia
- nonossifying fibroma
- radiolucent
- giant cell tumor
- unicameral bone cyst
- aneurysmal bone cyst
Osteoid Osteoma
benign ostoid forming tumor
- night pain
- <1cm cherry red lytic nidus
- Rx
- NSAIDs
- curettage/burring
- radiofrequency ablation
Osteoblastoma
large osteoid osteoma
- >2cm and more aggressive
- night pain
- nidus not visible on x-rays
- Rx
- NOT responsive to NSAIDs
- biopsy
- curettage and bone grafting
- tumor excision w/ bone reconstruction -or- internal fixation
Osteoma
benign deposit of new bone
- associated w/ Gardner’s syndrome (colonic polyps)
- firm w/ no pain
- typically on skull, tibia, femur
- Rx
- observation vs. marginal resection
Encondroma
benign cartilage formation in medullary canal
- associated with:
- Ollier’s disease
- Maffucci’s syndrome (+hemangiomas)
- “scalloped”/thinning on x-ray
- Rx
- no tx if asymptomatic
- biopsy
- curettage w/ bone grafting
Periosteal Chondroma
benign hyaline cartilage formation on surface of bone
- painful, sometime palpable mass
- saucerization w/ sclerosis on x-ray
- Rx
- excision
- need to r/o condrosarcoma
Osteochondroma
exostosis - growth on bone surface covered w/ benign cartilaginous cap
- pedunculated vs. sessile stalk
- Rx
- asymptomatic - monitor
- surgical excision
Chondroblasoma
cartilage forming tumor in epiphysis
- radiographic finding - well circumscribed/defined lytic lesion
- histology: “chickenwire calcification”
- Rx
- curettage and bone graft
Nonossifying Fibroma
(NOFs)
proliferation of fibrous tissue / fibrous cortical defect
- children/adolescents
- Jaffe-Campanacci Syndrome: multiple NOFs and cafe au lait spots
- Rx
- observation vs. curettage w/ bone graft
Fibrous Dysplasia
abnormal tissue formation in place of lamellar bone
- pain
- “ground glass” appearance on x-ray
- Rx
- surgery - rigid fixation
- Bisphosphates
Giant Cell Tumor
aggressive benign proliferation of multinucleated giant cells
- pain, swelling, deformity - can met to lungs
- lucent and ecentrically located, bony destruction/cortical breakthrough on x-ray
- Rx
- curettage, ablation, bone grafting, fixation
Unicameral Bone Cyst
fluid filled cyst w/ fibrous lining
- usually incidental finding or mild pain/swelling/stiffness
- Rx
- r/o sarcoma
- interlesion aspiration w/ corticosteroid injection
- curettage and bone graft
Aneurysmal Bone Cyst
aggressive vascular lesion w/ blood filled cavities
- Rx
- curettage and bone grafting
Metatastic Disease
carcinomas of other organs spread to the bones
most common bone tumor
Multiple Myeloma
proliferation of malignant interosseous plasma cells
in bone marrow
- “punched out” roundish lesion in x-ray
- Rx
- surgical fixation of pathologic fxs
- chemo/radiation
Osteosarcoma*
most common malignant bone tumor
- palpable mass, lymphadenopathy
- +/- pain, swelling, night pain
- types:
- telangiectatic
- multifocal
- parosteal
- periosteal - “star burst”/”sun burst”
- Rx
- resection to spare limb
- amputation
Chondrosarcoma
malignant predominantly cartilage tumor
- pain over time w/ or w/out mass
- symptoms depend on tumor location
- “ring and arc” pattern on x-ray, punctate calcifications, scalloping
- Rx
- excistion: wide resection vs. limb sparing
- NO chemo/radiation
Secondary Chondrosarcoma
arises from enchondroma/osteochondroma
- scattered irregular calcification on x-ray
Ewing Sarcoma*
malignant endothelioma -
assoc w/ chromosomal translocation t(11:22)
- young population
- worsening pain, fever, warmth, incr sed rate, WBCs (mimics infection)
- destructive lesion w/ poor borders on x-ray
- Rx
- chemo
- Vincristine, Cyclophosphamide
- radiation
- surgical resectioning
- limb sparing, amputation rare
- chemo
osteocyte receptors/inhibitors regulating osteoclast production
RAKLE and OPG
these determine rate of bone resorption
peak bone mass
18-20: proximal femur
25-30: spine
more loss than formation after this
bone physiology vs. pathology
longitudinal growth, mineralization, remodelling
growth - abnormal size
mineralization - osteomalacia
remodelling - osteoporosis
Osteoporosis
bone remodelling pathology
- no S/s - seen with associated fracture
- Kyphosis - Dowager hump
- FRAX tool
-
Dual-Energy X-ray Abosorbtiometry (DEXA) - gold standard
- T-score: value vs. control at peak BMD
- 1 STD = normal
- (-)1-2.5 STD = osteopenia
- (-)2.5+ = osteoporosis
- Z-score: value vs. age/sex
- >(-)2 = normal
- <(-)2 = below expected range
- T-score: value vs. control at peak BMD
- Rx
- Ca (1000-1200mg/d) + Vit D (600-800 IU/d)
- Bisphosphates - inhibit osteoclasts
- oral
- Alendronate (Fosamax)
- Risedronate (Actonel)
- Ibnadronate (Boniva)
- parental
- Zoledronic acid (Reclast)
- Ibandronate (Boniva)
- oral
- newer/expensive options
- selective estrogen receptor modulators (SERMs)
- Raloxifene (Evista)
- recombinant human parathyroid hormone
- Teriparatide (Forteo)- black box
- human monoclonal antibody
- Denosumab (Prolia)- RANKL Ab inhibits osteoclast
- selective estrogen receptor modulators (SERMs)
Osteomalacia
decreased mineralization
(softening of bone/rickets-children)
- Vit D deficiency, renal/liver disease, minerailzation inhibitors
- +/-Chvostek’s sign: tap on facial nerve elicits twitch
- 25-hyroxyvitamin D (<30 insufficient, <15-20 dificient)
- Rx
- Vit D replacement 400-2000 IU/d
Paget Disease
localized bone remodeling disorder
- deformities, abnormal gait, skull: hearing loss/HA/tinitis/increased hat size
- urinalysis: hyroxyproline, dexypyridinoline, C-telopeptide
- NOT a Vit D disorder
- Rx
- Bisphosphates
- Zoledronate acid (Reclast)
- Alendronate (Fosamax)
- Risedronate (Actonel)
- Bisphosphates
The 4 Spondyloarthropathies
share genetic predisposing factors and clinical features
- ankylosing spondylitis
- reactive arthritis
- psoriatric arthritis
- enteropathic arthritis
- joint ankyloses (new bone formation)
- occular inflammation
- HLA-B27 gene
Ankylosing Spondylitis
axial skeleton inflammation disorder
- HLA-B27
- achilles tendon/heel pain
- Schober test: measure mobility of spine 10cm/5cm
- “bamboo spine” on x-ray, SI joint “missing”
- Rx
- NSAIDs, corticosteroid (injection/systemic)
- Sulfasalazine
- Methotrexate
- DMARDs
- anti-TNF therapy
Reactive Arthritis
aseptic joint inflammation after infection
- salmonella, ersinia, shigella, chlamydia
-
Reiter’s syndrome: “can’t see, can’t pee, can’t climb tree”
- conjunctivitis, urethritis, conjunctivitis
- Mucocutaneous lesions/Papulosquamous eruptions
- HLA-B27
- synovial fluid analysis
- Rx
- no cure - self limiting
- NSAIDs +/- intra-articular injection
Psoriatric Arthritis
- onycholysis, subungual keratosis, pitting, oil staining
- HLA-B27
- Rx
- pain control, anti-TNF
Enteropathic Arthritis
non-erosive asymmetric polyarthritis
- associated w/ Crohn’s and UC
Scleroderma - Systemic Sclerosis
autoimmune thickening of skin/connective tissue
w/ internal organ involvement
- inflammation -> vascular obliteration -> fibrosis
- limited
- trunk spared
-
CREST syndrome
- Calcinous cutis, Raynaud’s, Esophageal thickening, Sclerodactyly, Telangiectasia
- diffuse
- proximal and trunk skin, rapid progression
- mixed
- overlap of SLE and systemic sclerosis (scleroderma)
- localized
- children - morphea (reddish/purple lesion)
- Rx
- no real tx - treat systems involved
- corticosteroids, methotrexate, D-penicillamine, ACE inhibitor
Osteoarthritis
progressive irreversible loss of articular cartilage
- changes to ALL components of joint: bone exposure, bony cysts, sclerosis of bony margins
- Heberden’s nodes (DIP)
- Bouchard’s nodes (PIP)
- Rx
- conservative
- RICE, hyaluronic acid/corticosteroid injections
- NSAIDs
- PT, lifestyle modification
- joint replacement
- conservative
Rheumatoid Arthritis
immune response in synovial tissue
- symmetric “moring stiffness” (gel phenomenon)
- MCP/PIP, C1-C2 subluxation
- deformities:
- ulnar deviation, swan-neck, Boutonniere, nodules, hammer toe
- Felty’s syndrome: RA, splenomegaly, neutropenia
- +RF/anti-CCP
- Rx
- no cure
- NSAIDs or low dose Prednisone
- DMARDs: methotrexate
- Anti-TNF: infliximab, adalimumab, golimumab
RA vs. OA
Gout
monosodium urate crystals (MSU)
- 1st metatarsophalangeal joint (Podegra)
- subcutaneous tophus
- synovial fluid analysis (gold standard)
- needle shaped crystals w/ negative birefringence
-
Rx
- lifestyle
- acute attacks: RICE, NSAIDs, Colchicine
- Xanthine oxidase inhibitor
- Allopurinol (Zyloprim, Aloprim)
- Probenecid (under-excreters)
- Pegloticase (Krystexxa) - rheumatologic, black box
Calcium Phyrophosphate Dihydrate Crystal Deposition Disease
(CPPD Crystal Deposition Disease)
extracellular PPi accumulation around chondrocytes
- synovial fluid analysis - gold standard
- square crystals w/ positive birefringence
-
types
- pseudo gout (single knee)
- chondrocalcinosis (incidental)
- pyrophosphate arthropathy (OA+CPPD)
- Rx
- RICE, NSAIDs, corticosteroids
Hydroxyapatite Arthropathy
(3 manifestations)
species of basic phosphate crystals
in joints, ligaments, tendons, bursa
- calcific tendinitis - sudden onset pain w/out MOI, resolves, back during resorption phase
- Milwaukee shoulder - crystals destroy RC and shoulder joint
- Diffuse idiopathic skeletal hyperostosis (DISH) - bridging in spine
Septic Bursitis
infection of bursa
- if infection of joint - pt will not want to move it!
- aspiration to identify infection
- Rx
- outpatient
- penicillin
- tri/sulfa (Bactrim) if MRSA
- Clindamycin -or- Linezolid if PCN allergy
- inpatient
- Nafcillin, Oxacillin, Cefazolin IV
- MRSA: add Vanco, Daptomycin, Linezolid
- outpatient
Septic Arthritis
infection of joint
- damages articular cartilage and bone - DON’T MISS
- hematogenous w/ UTIs, indwelling catheters
- very painful, red, hot, swollen, +/- fever
- cervical/urethral cultures if +gonococcal
- Rx
- surgery + IV antibiotics
Osteomyelitis
infection of bone
- biopsy or culture (gold standard)
- Rx
- abx spacer; reconstruction; amputation
- IV abx
- methylmethacrylate beads
Cervical Test
spurling
- narrows foramen
- will increase or reproduce radicular symptoms
Lumbar Tests
- straight-leg raise
- herniated disk
- lumbar spine of asymptomatic side
- seated straight-leg raise
- sciatic tenson, pt leans back
- FABER
- figure 4
- hip/SI joint pathology
non-organic pain signs
Waddell signs
- nonorganic tenderness
- axial stimulation/torso rotation
- seated straight-leg raise
- sensory examination
cervical strain
- Rx
- NSAIDs, pain meds, muscle relaxers, corticosteroids