MSK conditions Flashcards

1
Q

list some conditions that may present as back pain

A

Pregnancy
* Cancer
* Flu
* Colds
* Chest Infection
* Arthritis & Osteoporosis
* Shingles
* Urinary-tract infections (Kidney infection)
* Obesity

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2
Q

pain in rheumatoid arthritis is unilateral, true or false

A

false, it is mostly bilateral.

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3
Q

some questions to ask when assessing the nature of pain in the MSK

A

whether the pain is;
Localised or diffuse
* Unilateral or bilateral
* Aching or sharp
* Present only with use
* Present constantly
* Worse at night or at rest
* Associated with sensory symptoms

Can also Use of pain assessment tools

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4
Q

how do you diagnose rheumatoid arthritis

A

Patient history

Blood tests for inflammatory markers like RF and CCP

pain in rheumatoid arthritis is bilateral in the joints

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5
Q

some symptoms of RA

A

joint pain, swelling, stiffness, and inflammation, Redness and warmth around the joints
Bumps under the skin around affected joints

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6
Q

RA is an autoimmune condition true or false

A

true

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7
Q

the main markers to look out for in RA

A

RF(rheumatoid arthritis) Positive
CCP(Anti-cyclic citrullinated peptide ) Positive

CRP increased
ESR increased

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8
Q

corticosteroid effects in RA

A

Oral corticosteroids reduce inflammation systemically
* They also modify the body’s immune response. RA occurs as a result of immune disorder
* They act quickly - patients will start to feel better in a few days

note that they have significant side effects however

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9
Q

if RA diagnosed, what is the first line treatment

A

first-line treatment with conventional DMARD monotherapy using oral methotrexate, leflunomide or sulfasalazine as soon as possible and ideally within 3 months of onset of persistent symptoms.

Dose to be escalated as required(beware of side effects)

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10
Q

why are DMARDs first line when RA is diagnosed

A

the modify the course of the disease by slowing or halting it’s progression

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11
Q

importants points patient should know about methotrexate(HCP should tell them)

A

it’s a weekly dose (not daily)

Alcohol -induced liver disease increases the risk of hepatotoxicity in those taking Methotrexate. so do not take alcohol while on it

might start seeing effects within 3-4 weeks but may may take 3 months to see full effect

Patients and their carers should be warned to report immediately the onset of any feature of blood disorders (e.g. sore throat, bruising, and mouth ulcers), liver toxicity (e.g. nausea, vomiting, abdominal discomfort and dark urine), and respiratory effects (e.g. shortness of breath).

Patients and their carers should be advised to avoid exposure to UV light (including intense sunlight, sunlamps, and sunbeds)—see Important safety information.

Patients should be advised to avoid self-medication with over-the-counter aspirin or ibuprofen.

there’s a lot more to know, checkout the BNF or methotrexate purple book

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12
Q

is omeprazole a hepatic enzyme inducer or inhibitor

A

Omeprazole is a hepatic enzyme inhibitor rather than an inducer. Specifically, it inhibits cytochrome P450 (CYP) enzymes, particularly CYP2C19, and to a lesser extent CYP3A4.

this means it inhibits action of hepatic enzymes, thereby preventing the breakdown and therefore clearance of certain substances, like drugs. This could lead to more severe side effects from the drug

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13
Q

what is the interaction between methotrexate and trimetoprim

A

Trimethoprim is a folate antagonist(bacterial)

This leads to additive effect of folate antagonism(if on methotrexate)- bone marrow suppression
*
This interaction can be FATAL (has happened)
*
Also interaction between methotrexate and some penicillins (always check Stockleys)

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14
Q

when the dose esalation in RA is not effective, what does the nice guideline suggest we do

A

Offer additional cDMARDs (oral methotrexate, leflunomide, sulfasalazine or hydroxychloroquine) in combination in a step-up strategy when the treatment target (remission or low disease activity) has not been achieved despite dose escalation.

combination therapy more effective thatn single drugs

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15
Q

by which route is adalimumab administered

A

subcutaneously

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16
Q

when do we use biologics in RA

A

when combination therapy has not worked

note that symptom management esp with corticosteroids(for infammation) is required and important in RA

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17
Q

what is osteoporosis

A

A disease of low bone mass and structural deterioration of bone tissue, with a consequent increase in bone
fragility and susceptibility to fracture. characterised by porous bones. the more holes in the bones, the more severe osteoporosis is ( i guess)

osteopenia precursor to osteoporosis

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18
Q

diagnostic tools used to diagnose osteoporosis or osteopenia

A

DXA t score or DXA z score

  • FRAX tool
  • QFracture tool

the DXA scan measures bone density against a healthy young adult
-1 or higher: Bone density is normal
-1 to -2.5: Bone density is low, which is called osteopenia
-2.5 or lower: Bone density is very low, which is called osteoporosis

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19
Q

symptoms of osteoporosis

A

it is asymptomatic, and is often only diagnosed after a fragility fracture

A fragility fracture is defined as a fracture following a fall from standing height or less

vertebral fractures often painless and present later on as height loss

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20
Q

how do we diagnose osteoporosis

A

often after a first fracture (fragility )

through screening for osteoporosis (DXA)

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21
Q

should everyone be offered the DXA scan straight away if osteoporosis suspected?

A

no, some people should have a calculation of their osteoporosis risk first, with either the QFRACTURE or FRAX calculator. These both measure a 10-year probability of osteoporosis

22
Q

risk factors for osteoporosis

A

Sex
* Age
* Menopause
* Use of oral steroids
* Smoking
* Alcohol consumption
* Previous fragility fracture
* Rheumatological conditions
* Parental history of hip fracture
* BMI under 18.5kg/m2

23
Q

if the ten year risk for osteoporosis is >10%, what do we do

A

DXA scan offered

Following a DXA scan, bone sparing
treatment will be prescribed if a
patient’s T-score is less than -2.5

24
Q

how do we prevent osteporosis

A
  • A healthy diet for bones
  • Calcium
  • Vitamin D
  • Regular exercise
  • Avoiding smoking
  • Avoiding too much alcohol
  • Keeping to a healthy weight
25
first line treatments for osteoporosis
Bisphosphonates(alendronate, risedronate) * Calcium and Vitamin D ## Footnote alendronate, risedronate due to their broad spectrum of anti-fracture efficacy
26
how do bisphosphonates work
Bisphosphonates are adsorbed onto hydroxyapatite crystals in bone, slowing both their rate of growth and dissolution, and therefore reducing the rate of bone turnover. they increase bone density ## Footnote inhibits osteoclast activity
27
second line treatment for osteoporosis ## Footnote Used when bisphosphonates are not suitable or ineffective.
Denosumab , reduces osteoclast formation there are other second lines but this is the most common ( I think)
28
important counselling points for bisphosphonates
Atypical femoral fractures Patients should be advised to report any thigh, hip, or groin pain during treatment with a bisphosphonate. Osteonecrosis of the jaw During bisphosphonate treatment patients should maintain good oral hygiene, receive routine dental check-ups, and report any oral symptoms. Osteonecrosis of the external auditory canal Patients should be advised to report any ear pain, discharge from ear or an ear infection during treatment with a bisphosphonate. May interact with calcium products so do not take them together
29
where do we use HRTs in osteoporosis treatment
its use is generally restricted to younger postmenopausal women with menopausal symptoms who are at high risk of fractures. ## Footnote tibolone may be recommended as well in this case
30
lifestyle measures to be provided for those with or at risk of osteoporosis osteopenia
Weight bearing exercise * Calcium in the diet * Vitamin D – sun exposure * Stop smoking * Only drink alcohol within recommended limits ## Footnote examples of weight beaering exercises; walking, dancing, stair climbing, and racket sports.
31
after how long do we normally review bisphophonates
Bisphosphonates should be continued for 3-5 years, then reviewed
32
describe what is meant by soft tissue injuries
damage to the body's soft tissues, like damage to the body's soft tissues, like muscles, tendons, ligaments, fascia and synovial capsules leading to inflammation and pain ## Footnote more prevalent in sporty individuals. mostly due to physical activity
33
difference between a strain and sprain
A sprain is a stretch or tear in a ligament, which are the tough bands of tissues connecting your bones together (therefore occurs at a joint). here the joints are forced into an abnormal position while A strain is a stretch or tear in a muscle or tendon. aka pulled muscle or tendons. ## Footnote A tendon is the flexible tissue which connects muscles to bone.
34
causes of muscle sprains
*exercising – for example, playing sport *have strained a muscle in the past *fall *move or twist suddenly – for example, sprinting or catching a falling child *have a heavy blow to your muscle – for example when playing contact sports such as rugby *are overweight because this puts more stress on your muscles *do a repetitive movement that puts stress on your muscle – for example, painting a ceiling all day *don’t have enough strength in your muscles for the activity you’re doing not warming up properly before physical activity
35
signs and symptoms of a strain
Swelling Tender, red and warm to touch Weakness or instability Muscle spasm or cramping Inability to fully straighten your arm, leg, etc. Bruising (may take 24 hours before bruise fully appears) If you hear a pop or snap sound when you hurt yourself, you may have torn a ligament or broken a bone. ## Footnote note sprains are more likley to occur if history of previous sprains, as ligaments may be weaker, even after they have healed
36
signs and symptoms of a sprain
Stiffness or decreased movement Pain Painful “pop” that can be heard or felt Swelling or bruising Sometimes ‘instability in the joint’ can be felt “feels wobbly
37
which ligaments are most common to tear
the anterior cruciate ligament (ACL) and the medial collateral ligament (MCL)
38
signs and symptoms of a knee ligament injury
Pain, often sudden and severe **A loud pop or snap during the injury** Swelling within the first 24 hours after the injury **A feeling of looseness in the joint **Being unable to straighten the knee**** Inability to put weight on the joint without pain, or any weight at all
39
when do we refer soft tissue injuries
Marked swelling, bruising and pain occurring straight after injury. **Numbness in the injured area**. High impact injury – likely fracture, inability to full weight-bear Marked reduction in normal range of motion if there is Referred pain as it suggests nerve root compression; progressive pain suggests possible degenerative disease Bones are softer in children, more likely to get ‘greenstick’ fractures Elderly – establish risk factors/likelihood of underlying conditions (OA, OP) ## Footnote Referred pain is pain that's felt in a different part of the body than where the pain originates A greenstick fracture is an incomplete fracture, meaning the bone cracks on one side but doesn't break completely through, resembling a bent, partially broken green branch
40
treatment for sprains and strains
PRICE initially, then proceed to MICE after 3 days
41
what does the PRICE treatment stand for, include the specifics for each stage of treatment(eg, how long the stage should be for ) ## Footnote treatment for strains and sprains
Protect Rest (injured area should be rested for 48hours) Ice(10 - 20 mins at a time, 4-8 times per day) Compression Elevation( 6-8 inches above heart)
42
what does the MICE treatment stand for, include the specifics for each stage of treatment(eg, how long the stage should be for )
Movement (Gentle exercise to limit stiffness and promote healing) Ice (10 - 20 mins at a time, 4-8 times per day) Compression Elevation(6-8 inches above heart 3 days)
43
what do you do if someone comes to your pharmacy with a kneecap dislocation
refer to orthopaedic specialist, to be put back in place. this can take up to 6 weeks
44
pharmacological treatments for strains and sprains ## Footnote esp to manage symptoms
Analgesia – Paracetamol and Topical NSAIDs (Oral NSAIDs if still in pain) if the pain is persistent, them refer to a doctor as it could be a possible rupture
45
symptoms of a tendon injury
pain directly under the kneecap swelling and bruising in front of the knee a defect, or soft spot around the knee area difficulty walking or doing sports activities
46
describe the following tendinopathies; Tendinosis Tendonitis Tenosynovitis
Tendinosis – small tears in the tendons Tendonitis – inflammation of the tendons Tenosynovitis – inflammation of the tendon sheaths ## Footnote these are all usually due to overuse of the tendon
47
describe Patellofemoral pain syndrome
pain in the front of the kneecap which is due to overuse, injury, excess weight..etc being put on the knee
48
describe plica syndrome
thickening or folding of the ligaments
49
bursitis
a painful inflammation of the fluid-filled sacs that cushion joints. It's usually caused by repetitive motions or injuries. usually occurs in the shoulder, elbow, hip, knee, heel, and base of the big toe.
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