MSK conditions Flashcards
list some conditions that may present as back pain
Pregnancy
* Cancer
* Flu
* Colds
* Chest Infection
* Arthritis & Osteoporosis
* Shingles
* Urinary-tract infections (Kidney infection)
* Obesity
pain in rheumatoid arthritis is unilateral, true or false
false, it is mostly bilateral.
some questions to ask when assessing the nature of pain in the MSK
whether the pain is;
Localised or diffuse
* Unilateral or bilateral
* Aching or sharp
* Present only with use
* Present constantly
* Worse at night or at rest
* Associated with sensory symptoms
Can also Use of pain assessment tools
how do you diagnose rheumatoid arthritis
Patient history
Blood tests for inflammatory markers like RF and CCP
pain in rheumatoid arthritis is bilateral in the joints
some symptoms of RA
joint pain, swelling, stiffness, and inflammation, Redness and warmth around the joints
Bumps under the skin around affected joints
RA is an autoimmune condition true or false
true
the main markers to look out for in RA
RF(rheumatoid arthritis) Positive
CCP(Anti-cyclic citrullinated peptide ) Positive
CRP increased
ESR increased
corticosteroid effects in RA
Oral corticosteroids reduce inflammation systemically
* They also modify the body’s immune response. RA occurs as a result of immune disorder
* They act quickly - patients will start to feel better in a few days
note that they have significant side effects however
if RA diagnosed, what is the first line treatment
first-line treatment with conventional DMARD monotherapy using oral methotrexate, leflunomide or sulfasalazine as soon as possible and ideally within 3 months of onset of persistent symptoms.
Dose to be escalated as required(beware of side effects)
why are DMARDs first line when RA is diagnosed
the modify the course of the disease by slowing or halting it’s progression
importants points patient should know about methotrexate(HCP should tell them)
it’s a weekly dose (not daily)
Alcohol -induced liver disease increases the risk of hepatotoxicity in those taking Methotrexate. so do not take alcohol while on it
might start seeing effects within 3-4 weeks but may may take 3 months to see full effect
Patients and their carers should be warned to report immediately the onset of any feature of blood disorders (e.g. sore throat, bruising, and mouth ulcers), liver toxicity (e.g. nausea, vomiting, abdominal discomfort and dark urine), and respiratory effects (e.g. shortness of breath).
Patients and their carers should be advised to avoid exposure to UV light (including intense sunlight, sunlamps, and sunbeds)—see Important safety information.
Patients should be advised to avoid self-medication with over-the-counter aspirin or ibuprofen.
there’s a lot more to know, checkout the BNF or methotrexate purple book
is omeprazole a hepatic enzyme inducer or inhibitor
Omeprazole is a hepatic enzyme inhibitor rather than an inducer. Specifically, it inhibits cytochrome P450 (CYP) enzymes, particularly CYP2C19, and to a lesser extent CYP3A4.
this means it inhibits action of hepatic enzymes, thereby preventing the breakdown and therefore clearance of certain substances, like drugs. This could lead to more severe side effects from the drug
what is the interaction between methotrexate and trimetoprim
Trimethoprim is a folate antagonist(bacterial)
This leads to additive effect of folate antagonism(if on methotrexate)- bone marrow suppression
*
This interaction can be FATAL (has happened)
*
Also interaction between methotrexate and some penicillins (always check Stockleys)
when the dose esalation in RA is not effective, what does the nice guideline suggest we do
Offer additional cDMARDs (oral methotrexate, leflunomide, sulfasalazine or hydroxychloroquine) in combination in a step-up strategy when the treatment target (remission or low disease activity) has not been achieved despite dose escalation.
combination therapy more effective thatn single drugs
by which route is adalimumab administered
subcutaneously
when do we use biologics in RA
when combination therapy has not worked
note that symptom management esp with corticosteroids(for infammation) is required and important in RA
what is osteoporosis
A disease of low bone mass and structural deterioration of bone tissue, with a consequent increase in bone
fragility and susceptibility to fracture. characterised by porous bones. the more holes in the bones, the more severe osteoporosis is ( i guess)
osteopenia precursor to osteoporosis
diagnostic tools used to diagnose osteoporosis or osteopenia
DXA t score or DXA z score
- FRAX tool
- QFracture tool
the DXA scan measures bone density against a healthy young adult
-1 or higher: Bone density is normal
-1 to -2.5: Bone density is low, which is called osteopenia
-2.5 or lower: Bone density is very low, which is called osteoporosis
symptoms of osteoporosis
it is asymptomatic, and is often only diagnosed after a fragility fracture
A fragility fracture is defined as a fracture following a fall from standing height or less
vertebral fractures often painless and present later on as height loss
how do we diagnose osteoporosis
often after a first fracture (fragility )
through screening for osteoporosis (DXA)
should everyone be offered the DXA scan straight away if osteoporosis suspected?
no, some people should have a calculation of their osteoporosis risk first, with either the QFRACTURE or FRAX calculator. These both measure a 10-year probability of osteoporosis
risk factors for osteoporosis
Sex
* Age
* Menopause
* Use of oral steroids
* Smoking
* Alcohol consumption
* Previous fragility fracture
* Rheumatological conditions
* Parental history of hip fracture
* BMI under 18.5kg/m2
if the ten year risk for osteoporosis is >10%, what do we do
DXA scan offered
Following a DXA scan, bone sparing
treatment will be prescribed if a
patient’s T-score is less than -2.5
how do we prevent osteporosis
- A healthy diet for bones
- Calcium
- Vitamin D
- Regular exercise
- Avoiding smoking
- Avoiding too much alcohol
- Keeping to a healthy weight