MSK and rheumatology Flashcards
1
Q
What is the diagnostic criteria for osteoporosis?
A
- T score ≤2.5
- Minimal trauma fracture
2
Q
What is the bone turnover marker indicating resorption?
A
b-CTX
3
Q
What is the bone turnover marker indicating formation?
A
P1NP
4
Q
What are some common secondary causes of osteoporosis?
A
- Cushing’s syndrome, exogenous corticosteroids
- Excessive alcohol use
- Smoking
- Malabsorption
- Primary or secondary hypogonadism
5
Q
What is the mechanism of action of bisphosphonates?
A
Inhibits osteoclast formation and promotes apoptosis
6
Q
What are the adverse effects of bisphosphonates?
A
ONJ, atypical fractures
7
Q
How do you assess disease damage in RA?
A
MRI
8
Q
How do you assess disease activity in RA?
A
- Global assessment
- Swollen and tender joint count
- CRP/ESR
