MSK Flashcards
Amyloidosis - Management
FL: bortozemib, lenalinomide, dexamethasone (protease inhib, IMD, steroid)
HDM-ASCT is preffered in younger, more fit patients with less severe Dx
Amyloidosis disease monitoring
Free light chain
or M-protein
Amyloidosis Complications and Management
Nephrotic syndrome: loop diuretic, salt restriction ?human albumin
CKD: monitor function, dialysis if nec. Transplant only if low extra-renal amyloid or clonal remission
Hypertension: ACEi, ARB
CHF: loop diuretic
Prognosis of amyloidosis
Untreated is progressive and fatal
Cardiac involvement bad sign
Avg. survival is now years but depends on organs affected
Achilles tendinosis Define
Tendon degeneration (not inflammatory state) causing disruption of collagen fibres.
Achilles tendinosis epi
200:100,000 annual incidence
Common amongst active people - most commonly middle aged and middle/long distance runners
Aetiology/Risk factors for achilles tendinosis
Fluoroquinonlones
DM
Hyperlipidaemia
Achilles tendinosis history
Aching (sometimes sharp) in heel made worse on activity
Stiffness in tendon
Mid point: pain 2-6cm proximal to insertion that limits activity
Insertional: pain and swelling at insertion on posterior calcaneus
- Can have both
Risk factors: DM, dyslipidaemia, fluoroquinolone use
Achilles tendinosis examination
Examine both legs look for: redness, swelling, asymmetry
Palpate tendon assessing: tenderness, heat, crepitus, thickening, nodularity (is it distal or mid point)
Pain worsens with passive dorsiflexion
achilles tendinonsis investigations
VISA-A questionnaire indicates severity
Clincal Dx so imaging not usually indicated
Arrange Ix for lipids/HbA1c if riak factors likely
Achilles tendinosis management - primary care
Primary care:
Manage underlying cause (fluoroquinolones, DM, hypercholesterolaemia)
Self care (ice packs, paracetamol, rest, weight bear as tolerated)
Refer to physio if not improved after 7-10 days
NOT CORTICOSTEROIDS
If chronic or fails to respond arrange sports physician/ortho referral
Achilles tendinosis management - secondary care
Secondary care:
Exercise programme (eccentric contraction based)
Extracorporeal shock wave therapy - acoustic waves may help diseased tissue - uncertain efficacy
Surgery: if chronic and unresponding, debridement and removal of diseased tendon
Achilles tendinosis complications
rupture
irreversible degeneration
Achilles tendinosis prognosis
Pain can take weeks-months to resolve
If adequate management not undertaken can go into degenerative tendinopathy which may be irreversible
Achilles rupture epi
18:100,000 annual incidence
Mean age 37-44