MSK Flashcards
Which drug causes reactivation of TB
TNF alpha inhibitor (etanercept and infliximab)
What are the symptoms of cubital tunnel syndrome and what nerve is compressed
Tingling in the ring and middle finger. The ulnar nerve is trapped in the cubital fossa
How do you treat necrotising fasciitis
Debridement, penicillin and clindamycin
What DMARD causes interstitial pneuomonitis
Methotrexate
What rheumatic drug causes tarry black stool
NSAIDs
What rheumatic drug is a nephrotoxic
Gold and penicillamine
What is another side effect of penicillamine (other than nephrotoxicity)
Pneumonitis
What are symptoms of bechet’s syndrome
Visual loss, mouth ulcers and genital ulcers.
What bloods are raised in bechet’s syndrome and what other conditions is it related to?
It’s associated with IBD, arthritis and is from a HLA-B51 lineage. CRP and ESR are raised
What DMARD caused bone symptoms (osteoporosis)
Predinsolone
Describe rheumatoid arthritis
A chronic inflammatory disease (type IV hypersensitivity) causing symmetrical deforming, polyarthritis and systemic disease.
What is the synovial full of in rheumatoid
Macrophages, fibroblasts and giant cells
Tests for RA
High inflammatory markers, and positive rheumatoid factor. Anti CCP antibodies
What are the differences between OA and RF
OA is asymmetrical, non inflammatory and usually involved in older patients
What are the 4 x-ray signs of OA
LOSS: Loss of joint space Osteophytes Subchondral sclerosis Subchondral cysts
What are nodes on the DIP and PIP caused
DIP: Herberden’s nodes
PIP: Bouchard’s nodes
Treatment of OA
Physio, topical NSAIDs, paracetamol and joint replacement
What are symptoms of a simple backache
20-55 years old, well patient, back/buttock/thigh pain, normal neurology, pain changes with position or movement
What are symptoms of nerve root pain
unilateral leg pain, paraesthesia in same distribution, leg>back pain, abnormal neurology, weakness, reflex/sensory changes, nerve stretch pain),