Dermatology Flashcards
What type of dermatological condition has this histology
Wart
What type of dermatological condition has this histology
Psoriasis
What type of dermatological condition has this histology
Rash
Couldn’t be bothered cropping lol
Pemphigus and pemphigoid
What type of skin is this?
Palmar skin
Label the following diagram
A: Nail Plate
B: Lanula
C: Nail root
D: Cuticle
E: Nail matrix
F: Nail bed
G: Hyponychium
H: Free edge of nail
What are signs of acute intermittent porphyria?
Abdo pain, pain on urination, psychaitric signs, fast pulse and a high BP
Build up of what occurs in porphyria cutanea tarda and what enzyme defiency causes this
Build up of uroporphinogen III due to uroporphinogen decarboxylase deficiency
What could be a cause for a child crying when in direct sunlight? What build up and what enzyme deficiency?
Protoporphyria (build-up of protoporphyrin 9 due to ferrochelatase deficiency)
What causes acute intermittent porphyria
Build up of porphobilinogen due to deficiency of porphobilinogen deaminase
What are symptoms of porphyria cutanea tarda?
Onycholysis (nail detachment), blistering of sun exposed skin, hyperpigmentation, hypertrichosis
What are symptoms of erythropoetic protoporphyria
Painful photsensitivity with a burning/itching sensation
First line treatment of rosacea
Topical metronidazole
First line treatment for acne vulgaris
Benzyl peroxide or topical clindamycin??
What is epidermolysis bullosa?
Inherited breakdown of anchoring between epidermis and dermis
What genetic defect causes epidermyolysis?
Simplex: AD KRT5 and KRT14 gene issues
Junctional: AR laminin and collagen issue
Dystrophic caused by AD or reciessive COL7A1 gene issue
Describe psoriasis presentation
Red, flaky, crusty plaques of skin covered ith silvery scales normally on elbows, knees, scalp and lower back. Can be itchy and painful. Usually develops in under 35s
Treatment of psoriasis
Topical corticosteroid or vitamin D3 analogue as first line
Or coal tar/keratolytic
What are three causes of neurogenic pruitis
CNS receptors effect due to thyroid disease or malignancy
How to diagnose pemphigus/pemphigoid
Biopsy with immunofluorescence
Describe toxic epidermyl necrolysis
A severe acute superficial desquamating eruption often secondary to drugs e.g. antibiotics and presents with fever, malaise, painful erosions and generalised erythema
Do creams cause more contact sensitisation that ointments?
Yes because they contain more preservatives
What dermatological condition is associated to coeliac
Dermatitis herpetiformis
