MSK

Question 1

meloxicam, piroxicam.

Answer 1

NSAID
MECHANISM Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis.
CLINICAL USE Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.
ADVERSE EFFECTS Interstitial nephritis, gastric ulcer (prostaglandins protect gastric mucosa), renal ischemia
(prostaglandins vasodilate afferent arteriole), aplastic anemia.

Question 2

ketorolac

Answer 2

NSAID
MECHANISM Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis.
CLINICAL USE Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.
ADVERSE EFFECTS Interstitial nephritis, gastric ulcer (prostaglandins protect gastric mucosa), renal ischemia
(prostaglandins vasodilate afferent arteriole), aplastic anemia.

Question 3

diclofenac

Answer 3

NSAID
MECHANISM Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis.
CLINICAL USE Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.
ADVERSE EFFECTS Interstitial nephritis, gastric ulcer (prostaglandins protect gastric mucosa), renal ischemia
(prostaglandins vasodilate afferent arteriole), aplastic anemia.

Question 4

Sevelamer

Answer 4

Phosphate binder - used in CKD patients

Question 5

Pegloticase

Answer 5

Pegloticase Recombinant uricase that catalyzes metabolism of uric acid to allantoin (a more water-soluble
product).

Question 6

certolizumab

Answer 6

Anti-TNF-α monoclonal antibody.
Tx of Inflammatory bowel disease, rheumatoid arthritis,
ankylosing spondylitis, psoriasis

Question 7

golimumab

Answer 7

Anti-TNF-α monoclonal antibody.
Tx of Inflammatory bowel disease, rheumatoid arthritis,
ankylosing spondylitis, psoriasis

Question 8

Hydroxychloroquinine

Answer 8

DMARD