Biochem

Question 1

Pyrimethamine

Answer 1

Inhibits dihydrofolate reductase inhibiting the production of deoxythymidine monosphosphate in protozoa.

Question 2

Mycophenolate

Answer 2

Inhibits IMP dehydrogenase which converts IMP into GMP, used for immunosuppression.

Question 3

Teniposide

Answer 3

Inhibits eukaryotic topoisomerase II
tx: testicular cancer
small cell lung cancer 
leukemias and lymphomas 
AE: myelosuppression, diarrhea

Question 4

Fomepizole

Answer 4

inhibits alcohol dehydrogenase, antidote

For Overdoses of Methanol and Ethylene glycol

Question 5

Disulfiram

Answer 5

inhibits acetaldehyde dehydrogenase (acetaldehyde accumulates contributing to hangover symptoms.

Question 6

Dimercaprol

Answer 6

antidote for arsenic poisoning

Question 7

Benzoate
Phenylacetate
Phenylbutyrate

Answer 7

these drugs react with glycine or glutamine, forming products that are renally excreted.

Question 8

Penicillamine

Answer 8

Chelating agent to increase the solubility of cysteine stones

Question 9

Nevirapine

Answer 9

NNRTI that isn’t contraindicated in pregnancy.

Question 10

Cytarabine

Answer 10

Pyrimidine analog > DNA
chain termination. At higher
concentrations, inhibits DNA
polymerase.
Leukemias (AML), lymphomas. Myelosuppression with
megaloblastic anemia.
CYTarabine causes
panCYTopenia.
*note only treats hematologic malignancies

Question 11

Gemcitabine

Answer 11

Pyrimidine analog > DNA
chain termination. At higher
concentrations, inhibits DNA
polymerase.
Tx: Hematologic malignancies and solid tumors.