MSK Flashcards
1
Q
genetic RF for osteoarthritis
A
COL2A1 collagen type 2 gene
2
Q
pathophysiology of osteoarthritis
A
inflammatory cytokines interrupt normal repair of cartilage damage
3
Q
osteoarthritis signs
A
Heberden’s and Bouchard’s nodes, fixed flexion deformity of carpometacarpal, mucoid cysts
4
Q
osteoarthritis symptoms
A
morning stiffness <30 mins, joint pain worse w activity, mechanical locking, joint tenderness, cerpitus
5
Q
osteoarthritis xray
A
LOSS: loss of joint space, osteophytes, subarticular sclerosis, subchondral cysts
6
Q
osteoarthritis pharmacological 1st line treatment
A
oral paracetamol + topical NSAID + topical capsaicin
7
Q
osteoarthritis surgical tx
A
intra-articular steroid injection, arthroplasty, arthroscopy
8
Q
rheumatoid arthritis gene
A
HLA-DR1 and DR4
