MSCK

Question 1

Epi of Rahbdomyosarcoma

Answer 1

Most common soft tissue Sarcoma
of children

Question 2

Varients of Rhamdomyosarcoma

Answer 2

1) Pleomorphic Rhabdomyosarcoma
2) Embryonal Rhabdomyosarcoma
3) Alveolar Rhabdomyosarcoma

Question 3

Microscopic featurs:
* Typical rhabdo-myoblasts with eccentric eosinophilic cytoplasm
* high cellularity
* “Cambium layer” of tightly packed tumour cells beneath the epithelium

features of?

Answer 3

Embryonal Rhabdomyosarcoma (of the SM)

Question 4

Embryonal Rhabdomyosarcoma

Microscopic featurs:
* Typical rhabdo-myoblasts with eccentric eosinophilic cytoplasm
* high cellularity
* “————–” of tightly packed tumour cells beneath the epithelium

* eccentric : deviating away from the center

Answer 4

Microscopic featurs:
* Typical rhabdo-myoblasts with eccentric eosinophilic cytoplasm
* high cellularity
* “Cambium layer” of tightly packed tumour cells beneath the epithelium

Question 5

Microscopic features:
* Tumour cells line hollow spaces
* Fibro-vascular septa
* “Picket fence”-like arrangement

features of?

Answer 5

Alveolar Rhabdomyosarcoma

Question 6

Alveolar Rhabdomyosarcoma

Microscopic features:
* Tumour cells line hollow spaces
* Fibro-vascular septa
* “————–”-like arrangement

Answer 6

Microscopic features:
* Tumour cells line hollow spaces
* Fibro-vascular septa
* “Picket fence”-like arrangement

Question 7

immunohesitochemistry used to stain Monocytes

Answer 7

NADH-HR

Question 8

Histopatho:
▪ Involvement of both type I and type II fibres
▪ Small and angular fibers as well as target fibres
▪ Fibre Type grouping, after re-innervation

features of?

Answer 8

Denervation Atrophy

Question 9

what do you obsever , what condition causes this?

Answer 9

Target fibers caused by Denervation Atrophy

* traget fibers are normally found on type I fibers

Question 10

Lab findings of Duchenne Muscular dystrophy

Answer 10

Increased serum CK

Question 11

Microscopic findings:
Tangles of small rod-shaped granules (“Rod bodies”), predominantly in type I fibres

feature of?

Answer 11

Nemaline Myopathy

Question 12

Distinctive micro featurs of Nemaline Myopathy

Answer 12

“Rod bodies” in type I fibers

Question 13

CM of Nemaline Myopathy

Answer 13

Variable clinical presentation; from mild, non- progressive disease to severe weakness → Death from respiratory failure

Question 14

Microscopic features:
▪ “Ragged red” appearance of muscle fibres
▪ Various mitochondrial enzyme or co-enzyme defects (detected by immuno-histochemistry -NADH-TR)

features of?

Answer 14

Mitochondrial Myopathies

Question 15

Distinctive micro features found in Mitochondrial Myopathies

Answer 15

“Ragged Red” appearance of muscle fibers

Question 16

Microscopic featuers:
- Synovitis w/ Lymph-plasmacytic infiltrates and oedema
- Hyperplasia and hypertrophy of the synovial lining cells → finger-like villi
- Granulation tissue (pannus) over articular cartilage
- Extension of pannus to sub-chondral bone → gradual erosions of bones and cartilage
- Subcutaneous nodules
- Cystic change sof the ‘nercrobiotic’ centre
- fibrinoid necrosis
- palisading epithelioid macrophages

features of?

Answer 16

Rheumatoid arthritis

Question 17

Chracteristic Chronic joint changes in Rheumatoid arthritis

Answer 17

1) “Swan neck” deformity of the fingers
2) Botuonniere deformity of the thumb
3) Ulnar deviation of the MCP joints

Question 18

CM of Ankylosing Spondylitis

Answer 18

Involvement of the spine: Bone fusion “Bamboo spine”

Question 19

Which disorder is has the following manifestaiton?
fusion of spinal bones “Bamboo spine”

Answer 19

Ankylosing Spondylitis

Question 20

Type of Seronegtaive arthrits

CM of Psoriatic Arthritis

Answer 20

1) “Pencil-in-cup deformity of the joints (seen on Radiograph)
2) Nail pitting
3) skin and nail lesions
4) sausage-shaped DIP joints

Question 21

A patient comes in with the follwing CM:
1) Nail lesions
2) “Pencil-in-cup” deformities of the joints (Seen on Radiograph)
3) Nail pitting and
4) Sausage-shaped DIP joints

Diagnosis?

Answer 21

Psoriatic Arthritis

Question 22

cause of Osteoarthritis

Answer 22

Mechanical taruma
“Wear-and-tear” arthritis

Question 23

* Osteoarthritis

Morphologic Features:
- Fragments of ———- into synovial fluid
- ————–: Polished, ———– appearance of bone
- Sub-chondrally located cystic changes
- New bone (—————) formation
- charcteristic ”————“
- ———– and ————- nodes

features of?

Answer 23

• Fragments of Cartilage into synovial fluid
• Eburnation: Polished, ivory-like appearance of bone
• New bone (Sub-chondrally) and osteophyte (bony projections) formation
• charcteristic “Joint mice”
• Heberden and Bouchard nodes

Question 24

Morphologic features:
- Fragments of Cartilage into synovial fluid
- Eburnation: Polished, ivory-like appearance of bone
- New bone (Sub-chondrally) and osteophyte (bony projections) formation
- charcteristic “Joint mice”
- Heberden and Bouchard nodes

features of?

Answer 24

Osteoarthritis

Question 25

Where Are Heberden nodes located?

Answer 25

Osteophytes (bony projections) at the distal inter-phalangeal joints of the fingers

Question 26

Where are Bouchard nodes located?

Answer 26

Osteophytes at the proximal inter-phalangeal joints of the fingers

Question 27

Morphological feature of?

Answer 27

Osteoarthritis