mRNA degradation control

Question 1

degradation via microRNA

Answer 1

-Drosha clips loop and stem structure off
-DNA leaves
-Interacts with dicer
-now has slight over hangs
-Argonaut grabs RNA pulling off one of the top strand
-RISC complex (Argonaut plus RNA)
-If an mRNA around matched the risc complex will get cut and degrade at a much quicker rate

Question 2

Why have something that makes and degrades

Answer 2

Want RNA but to much of it can lead to a disease state to miRNA keeps it under control and degrades it

Question 3

Alzheimers

Answer 3

-Bace-1 produces beta-amyloids
-Bace-1 is stabilized by a LNCR
-miRNA–> RISC complex that can cut the LNCR
-Suppose to degrade the LNCR so we don’t have to stable to Bace-1 gene
-Having too many beta amyloids can cause a percentage of miss folding leading to plaques