Motor System Flashcards

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1
Q

What are the steps to preform motor movement?

A
  1. posterior cortex provides sensory information to the frontal cortex
  2. prefrontal cortex plans movements
  3. premotor cortex organizes movement sequences
  4. motor cortex produces specific movements
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2
Q

What is the Edward Evert’s experiment on the movement coding by neutrons in neocortex? What were his 3 major findings?

A

he recorded activity of neutrons int he wrist region of the motor cortex while monkeys flexed their wrists on a lever

he found that

  1. m1 neurons plan and initiate movement
  2. m1 neutrons increase firing to increased force of a movement (i.e. the heavier the pulley connected to the lever, then the more firing)
  3. motor cortex specifies the direction of the movement
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3
Q

What was Apostles Georgopoulos experiment on the movement of coding by neutrons in the neocortex? What are his 3 findings?

A

he recorded activity of neutrons in the motor cortex while monkey moved lever in different directions

he found that:

  1. each m1 neutron is maximally active to a particular direction (i.e. as level mores away from the monkey by 180 degrees then the neuron fires a lot but as it moves towards the monkey by 180 it fires less)
  2. activity is decreased in proportion to the displacement from the preferred direction
  3. conclusion: motor neurone calculate distance and direction of movement
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4
Q

What did martin and colleagues find in regards to the role of motor cortex in observing, remembering and imagining movement?

A

he found that theres increase blood flow to the hand region of the motor cortex when naming tools

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5
Q

What did Haueisen and Knosche find in regards to the role of motor cortex in observing, remembering and imagining movement?

A

pianists exhibit activation of the motor cortex when listening to music

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6
Q

What did Nyberg and colleagues find in regards to the role of motor cortex in observing, remembering and imagining movement?

A

that similar brain activation occurs during imagined movement and actual movement i.e. like imagining rolling ball on a table

i.e. in the brain imagining it shows that it will recruit the same cortex’s as the overt movements except without cerebellar activity because u aren’t actually moving and no sensory and motor feedbacks

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7
Q

What is the primary motor cortex? and how does it operate (by which model)

A

primary motor cortex sends command signals via neuronal population vector model

  • theres no individual neuron that codes for each direction and action of movements and its a fluid and dynamic way of producing movements that you have never done before
  • you would recruit the same set of neurons every time plus or minus other neuronal actions to get a different movement overtime
  • combining different movements will give you a new vector of movement
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8
Q

What three things need to be present in order to create a motor program within a motor plan?

A
  1. plan of action … planning of a program for action
  2. goal information: planning that involves a goal (has an end point)
  3. neuromuscular control information: muscles have to control this action
  • motor plan may or may not be open to sensory feedback, virtually all movements are except for ballistic movements which are quick, goalless movements which are not open to sensory feedback
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9
Q

What is coarticulation in motor plans?

A

relationship between what we do with our speech and our face muscles when we speak … i.e. vocal muscles

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10
Q

what is the experiment we did on coarticulation in class? what was the result?

A

the difference between the word “struck” and the word “strike”… we say STRIKE with a smile and STRUCK more non like a smile e

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11
Q

What is the experiment that shows how far in advance motor planning is made?

A

it basically is aiming to show how far and how advanced motor planning is observed by reading a sentence and then saying it out loud

results show that longer phrases take longer to initiate therefore have a longer motor planning phase
- when we are given the signal to start speaking, we say the shorter and easier sentence almost right away but we say the longer and more complex sentences after a few while

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12
Q

How is the cerebellum organized and what are 3 major regions of it?

A
  • its organized ipsilaterally
    1. the vermis region is the medial region of the cerebellum and if its lesioned in monkeys then they fall ipsilateral to that lesion
    2. the intermediate zone –> lesion in this area will cause difficulty in smooth movements (action or intentional tremors) … Nose test case –> touching your nose and then touching the experimenter’s nose… intentional tremors occur when person moves finger towards their nose or towards object of focus
    3. lateral zone (involved in motor planning) –> involved in ballistic movements (like over shooting the target when trying to reach for it..etc..), and Multi-joint movement (like decomposition of movement, breaking movement processes down into smaller components instead of one full component)
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13
Q

What does the experiment for cerebellum damage and overshooting (hypermetria) show?

A

in MEG (muscle EEG’s), it shows that in cerebellar lateral zone damage .. the agonist peaks later and has more than one agnost peak which means it shows jerkiness as well as an extended DELAY of the antagonist muscle peaking

in normal patient the agonist peaks first to preform the action and then it QUICKLY dies down after antagonist muscle takes

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14
Q

What was Fatch’s study with cerebellum and motor learning with Prism Goggles?

A

neurologically intact people learned over time how to throw and aim using prism glasses which shifted their view to the left, and then they also learned to le-learn after the prism was removed

in lateral cerebellum damaged patients, learning and re-learning where not shown upon addition of prism glasses and removal of prism glasses (lateral zone damage)

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15
Q

What are the 5 roles of the Supplementary Motor Area (SMA)?

A
  1. motor planning (anterior or primary motor cortex in the medial surface)
  2. state of readiness for action
  3. action initiation
  4. complex movements
  5. motor imagery
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16
Q

What does the experiment with muscle activation and SMA activation show in monkeys?

A

300 ms prior to the motor action starting, the SMA area has really high activation and the muscles have low activation

then starting and during the motor action, the SMA is still firing but muscles are firing more

SMA is activated before initiation of action and decreases a bit 50ms prior to the start of the action

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17
Q

what is the difference between SMA proper and pre-SMA in experiment?

A

SMA proper is located to the right of the anterior commissure which is at the posterior end and pre-SMA is located more towards the anterior/frontal region of the anterior commissure

the Presma is closer to the frontal region therefore its correlated to WHAT the object is (sensory)

the SMA proper is more focused on the action when firing than the object

18
Q

What are mirror neurons? (4)

A

neurons that fire when we see others make a movement

  • encode for a complete action
  • actions can be used for imitating and understanding other’s actions (empathy?)
  • can fill in the blanks when part of a movement is absent
19
Q

How were mirror neurons discovered and what was the result?

A

discovered accidentally in macquae monkeys

neurons would fire just by monkeys watching person do a complete goal-oriented action

fires when target is even anticipated in the dark!

20
Q

What is the major benefit of having mirror neurons in the animal world?

A

enables communication between a sender and reciver

21
Q

what are 2 major benefits in having mirror neurons in humans?

A
  1. mirror neurons have a role in self action, perception of action, self awareness and awareness of the intention and actions of others
  2. important for gestures and understanding verbal language
22
Q

where are mirror neurons mostly located in humans?

A

generally located in the left hemisphere

23
Q

What are the major steps in movement regulation in the basal ganglia?

A

substantia nigra –> caudate –> thalamus –> cortex –> movement

24
Q

What is one major disorder of the basal ganglia that affects the caudate-putamen?

A

huntington’s chorea

  • destroys cells in the caudate putamen
  • results in involuntary and exaggerated movements
25
Q

what does chorea mean and what does athetosis mean?

A

chorea means twitching and athetosis mean writhing (twisting, squirming..etc..)

26
Q

What is another major disorder of the basal ganglia that effects the substantia nigra?

A

Parkinson’s disease

  • loss of dopamine cells in the substantia nigra and its input to the basal ganglia
  • results in muscular rigidity and difficulty initiating and performing movements
27
Q

what are 3 affects of parkinson’s?

A
  1. akinesia: cannot initiate spontaneous movements
  2. bradykinesia: slow movement
  3. tremors (rigid) –> different from cerebellar tremors because they are ridgid and occur without action, and all the time
28
Q

What does the parking sons disease and handwriting show?

A

that it takes longer for parking sons patients to handwrite and they have less regulation of the velocity of actions due to rigid tremors

29
Q

What are 4 functions of the Anterior Cingulate Cortex (ACC)

A
  1. attention
  2. emotion
  3. novel or cognitive actions
  4. motor modulation
30
Q

what experiment was done by Thomas Paus to show motor modulation in ACC?

A

done by showing you a letter “A” and you press the counter letter “B” and then the task changes to “A” and then you press “M”. Simple manipulation of remapping motor system shows robust activity in the ACC

31
Q

What do PET scans show about the topographic organization of the ACC?

A

its topographically organized in eye movements, speech and hand actions.
- more posterior activity (closer to motor strip and parietal cortex) if its a motor task (i.e. move your fingers) but more anterior activation if you have a speech task (closer to brocas area) and in eye movements, its closer to the anterior and frontal eye fields when activated

32
Q

what is one experiment that involves the actions of the ACC?

A

the STROOP task: which shows that the ACC is involved in planning the difference between the words and the color

33
Q

What is the role of the parietal lobe and Motor control?

A

Anterior intraparietal sulks has been shown to be involved in visually guided action (seeing object and then grabbing it

shows that all regions associated with motor control are confined to the intrapaerital sulcus like eye movements, pointing and visually guided grasping

34
Q

What was the experiment done with AIP activation and thumb/finger grasping?

A

the AIP lights up when grasping with thumb and finger in contralateral hemisphere

35
Q

how does AIP light up when grasping with mouth?

A

when grasped with mouth, the region close to the intraparietal region seems to activate but theres a strong link between picking up things with our hands vs. mouths to eat it so it does fire up just not as robustly as grabbing with our hands

36
Q

What is one example of a cortical disorder?

A

Apraxia

37
Q

what is apraxia?

A

difficulty with skilled, sequential or purposeful movements that cannot be accounted for by lower level motor problems

38
Q

what is oral (buccofacial) apraxia?

A

occurs during frontal lobe lesions and its related to frontal and temporal lesions to the brocas area

39
Q

What is limb apraxia?

A

left parietal temporal regions

  • causes difficulty:
    1. pantomiming actions: task-doing action (i.e. pretending to stir a pot)
    2. imitating an action
    3. symbolic actions
    4. effector selection: picking out the right body part for the action like like picking up something with your left hand instead of left foot… its the correct side but not the correct effector
40
Q

What is colossal apraxia?

A

similar to split brain patients

tumor occurs around the corpus callusom and information cannot transfer quickly and efficiently across the hemispheres