Motor Control and Disorder of Action Flashcards
How do we control our movements?
- Using multiple muscles
- Precise timing (e.g. between the 2 hands)
- Multiple components of movement
What do ‘higher’ cognitive aspects of motor control include?
List 4 points
- Planning and timing
- Sequencing
- Imagery (cf mirror neurones)
- Expertise (e.g. sport, musical instrument)
What neurones are involved in imagery in motor control?
Mirror neurones
Visualisation when practicing an action
a. Planning and timing
b. Sequencing
c. Imagery (cf mirror neurones)
d. Expertise (e.g. sport, musical instrument)
c. Imagery (cf mirror neurones)
When learning a new musical piece, the individual makes little to no conscious effort when playing
a. Planning and timing
b. Sequencing
c. Imagery (cf mirror neurones)
d. Expertise (e.g. sport, musical instrument)
d. Expertise (e.g. sport, musical instrument)
List 3 ways we can apply ‘higher’ cognitive aspects of motor control
- How to best learn motor skills
- Rehabilitation of patients with difficulties with movement
- Using knowledge of human movements to
create artificial limbs/robots
What are the 4 key cortical motor areas in the brain?
- Primary Motor Cortex
- Premotor cortex
- Prefrontal cortex
- Parietal cortex
What is the key motor function of Primary Motor cortex?
Execution
What is the key motor function of Premotor cortex?
Preparation of actions
What is the key motor function of Prefrontal cortex?
Higher level of planning
What is the key motor function of Parietal cortex?
Sensory-motor links
Which key brain area does this motor function apply to?
Higher level of planning
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Which key brain area does this motor function apply to?
Execution
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
Which key brain area does this motor function apply to?
Preparation of actions
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
d. Premotor cortex
Which key brain area does this motor function apply to?
Sensory-motor links
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
b. Parietal cortex
What are the 3 characteristic of the Primary Motor cortex (M1)?
- Pre-central gyrus
- Somatotopic
organisation - Activation in particular
parts of M1 causes
movement of particular
body parts on opposite
side
Activation in particular
parts of _____ causes
movement of particular
body parts on opposite
side
Primary Motor cortex (M1)
Activation in particular
parts of Primary Motor cortex (M1) causes
…?
Movement of particular
body parts on opposite
side
How is the Primary Motor cortex (M1) organised?
Somatotopic organisation
What is Somatotopic
organisation?
Organised according to the particular body parts
What can be used to activate/stimulate parts of the Primary Motor cortex (M1)?
TMS
If the left hemisphere of the Primary Motor cortex (M1) is activate, what part of our body will move?
Right hand/arm will move
If the left hemisphere of the Primary Motor cortex (M1) is activate, our right hand/arm will move
This is known as…?
Somatotopic activation
What happens when there is a stroke affecting one side of the brain?
It can affect the movement of the opposite side of the body
_____ can affect the movement of the opposite side of the body
Stroke affecting one side
of the brain
What are the 2 types of brain lesions that can affect
movement of the opposite
side of the body?
- Hemiplegia
- Hemiparesis
Define Hemiplegia
Paralysis of one side of the body
Define Hemiparesis
Weakness of one side of the body
Paralysis of one side of the body
This is known as…?
Hemiplegia
Weakness of one side of the body
This is known as…?
Hemiparesis
e.g. Problems with face muscles on one side
a. Hemiplegia
b. Hemiparesis
a. Hemiplegia
Potential of rehabilitation
a. Hemiplegia
b. Hemiparesis
b. Hemiparesis
What 2 things are involved in normal motor control?
- Bilateral Premotor Planning
- Unilateral Primary Motor Execution
What 3 things are involved in stroke induced paresis/motor control?
- Ipsilateral Premotor Planning unaffected
- Contralateral Premotor Planning lost
- Primary Motor Execution Lost
Cells in _____ have a preferred direction of movement
Primary Motor cortex (M1)
Cells in Primary Motor cortex (M1) have a preferred …?
Direction of movement
Cells in Primary Motor cortex (M1) have a preferred direction of movement
What is the preferred direction?
Anywhere where there are high populations of
cells
What type of coding of movement do Primary Motor cortex (M1) cells follow?
Vector coding
What is vector coding in Primary Motor cortex (M1)?
When populations of cells code the direction of
movement
What are the 2 parallel systems in the Primary Motor cortex (M1) that form an integrate-isolate pattern?
- Body-part specific
for fine motor control of the foot, hand and mouth - Somato-cognitive action network (SCAN) for integrating goals and whole body movement
What pattern do the 2 parallel systems in the Primary Motor cortex (M1) form…?
An integrate-isolate pattern
- Body-part specific
for fine motor control of the foot, hand and mouth - Somato-cognitive action network (SCAN) for integrating goals and whole body movement
These are the systems in…?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
Where does the Primary Motor cortex (M1) receive input from?
List 3 points
- Supplementary motor area
- Premotor area
- Primary somatosensory area
Where does the Primary Motor cortex (M1) output signals/information to?
Spinal cord (for the control of muscles)
Why is the position of Primary Motor cortex (M1) and Primary Somatosensory cortex convenient?
List 3 points
- They are right next to each other
- It is quicker and easier for the Primary Somatosensory cortex to send information to the Primary Motor cortex (M1)
- The Primary Motor cortex (M1) would then send output signals to the spinal cord for the control of muscles
Receives input from:
- Supplementary motor area
- Premotor area
- Primary somatosensory area
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
Output to the spinal cord
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
What are the key areas of the Premotor cortex?
- Lateral Premotor Cortex
- Supplementary Motor Area – (Medial Prefrontal Cortex)
Lateral Premotor Cortex is an area in the…?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
d. Premotor cortex
Supplementary Motor Area is an area in the …?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
d. Premotor cortex
What region in the Premotor cortex is responsible for externally
generated actions?
Lateral Premotor Cortex
What region in the Premotor cortex is responsible for internally
generated actions?
Supplementary Motor Area – (Medial Prefrontal Cortex)
What is Lateral Premotor Cortex responsible for?
Externally generated actions
What is Supplementary Motor Area – (Medial Prefrontal Cortex) responsible for?
Internally generated actions
e.g. well learnt sequences that you know how to do already
Which region of the Premotor cortex does this apply to?
Generating actions of well learnt sequences that you know how to do already
Supplementary Motor Area – (Medial Prefrontal Cortex)
Which region of the Premotor cortex does this apply to?
Generating actions of novel sequences or unfamiliar movements
Lateral Premotor Cortex
Which region of the Premotor cortex does this apply to?
Voluntarily initiating movement, when and where to do it rather than how
Supplementary Motor Area – (Medial Prefrontal Cortex)
Areas more active in more difficult bimanual tasks
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
d. Premotor cortex
What 3 areas are more active in more difficult bimanual tasks?
- Cerebellum
- SMA
- Pre-motor area
Give an example of a bimanual task
Tasks across the hand
Drawing a circle clockwise with one hand while simultaneously drawing a circle anti clockwise with another hand
Cerebellum, SMA and Pre-motor areas are more active in more difficult bimanual tasks
What does this suggest about our coordination of movements?
We are good at coordinating our hands and separating them would make our everyday life difficult
What is sequence learning?
Practicing and learning temporal patterns of events little by little during the course of the experiment
How does sequence learning help us with our movements?
List 2 ways
- It helps produce faster and more accurate movements
- Movements change from effortful to automatic
Helps produce faster and more accurate movements
What contributes to this?
Sequence Learning
Movements change from effortful to automatic
What contributes to this?
Sequence Learning
What 4 regions of the brain become affected after sequence learning?
- Dorsolateral prefrontal cortex
- SMA
- Lateral premotor cortex
- Primary motor cortex
What happens to the Dorsolateral prefrontal cortex after sequence learning?
Decreases in activation
What happens to the SMA after sequence learning?
Increases in activation
What happens to the Lateral premotor cortex after sequence learning?
Decreases in activation
What happens to the Primary motor cortex after sequence learning?
Decreases in activation
After sequence learning, which of these brain regions decrease in activation?
a. SMA
b. Dorsolateral prefrontal cortex
c. Primary motor cortex
d. Lateral premotor cortex
b. Dorsolateral prefrontal cortex
c. Primary motor cortex
d. Lateral premotor cortex
After sequence learning, which of these brain regions increase in activation?
a. SMA
b. Dorsolateral prefrontal cortex
c. Primary motor cortex
d. Lateral premotor cortex
a. SMA
Why does the primary motor cortex decrease in activation after sequence learning?
Because once you have learned the sequence and have had sufficient practice, you are less likely to make less effort and movements since you are already familiar with it
What is the role of Dorsolateral prefrontal cortex?
Informal conscious control
What is the role of SMA?
Internal generation of movements
What is the role of Lateral Premotor Cortex?
External generation of movements
Other than the SMA, Dorsolateral prefrontal cortex, Primary motor cortex and Lateral premotor cortex, what other 2 brain regions are affected by sequence learning?
- Subcortical - cerebellum
- Basal ganglia
There are ____ muscles involved as more sequence learning takes place
a. Fewer
b. More
a. Fewer
Describe Gerloff et al.’s (1997) study and results on using the TMS to block activity in the SMA
List 2 points
- Repetitive TMS to
block activity in a particular brain area for a period of time during simple, scale and complex piano sequence tasks - SMA only interfered
with performing the
most complex
sequence
Repetitive TMS to
block activity in a particular brain area for a period of time during simple, scale and complex piano sequence tasks
What did the SMA only interfered with?
Only interfered with performing the most complex sequence but not simple or scale sequences
List one evidence of the SMA
SMA only interfered
with performing the
most complex
sequence but not simple or scale sequences
Suggests its importance in complex sequence tasks
Important for complex sequence tasks
a. SMA
b. Dorsolateral prefrontal cortex
c. Primary motor cortex
d. Lateral premotor cortex
a. SMA
Only interfered with performing the most complex sequence
a. SMA
b. Dorsolateral prefrontal cortex
c. Primary motor cortex
d. Lateral premotor cortex
a. SMA
Choosing what action to perform involves which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
For longer term goals and intentions
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Attention to action – when difficult or
learning
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Not specific to action, e.g. generating random numbers
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
What are the 4 characteristics of Prefrontal cortex?
- Choosing what action to perform (e.g. which finger, Frith et al. 1991)
- Attention to action – when difficult or learning
- Longer term goals and intentions
- Not specific to action, e.g. generating random numbers
When do we pay more attention to our actions?
When the actions or difficult or when learning new actions
What are the 4 types of prefrontal cortex lesions?
- Perseveration
- Utilisation behaviour
- Disinhibition
- Frontal apraxia
Define Perseveration
Repeating the same action when it is no longer relevant
Define Utilisation behaviour
When the person acts on an irrelevant (or inappropriate) object in environment
e.g. Visiting your neurologist and putting on their glasses, inappropriate social behaviour
Define Disinhibition
The inability to withhold an inappropriate or unwanted behaviour
e.g. antisaccade task
Person is asked to not look at the light flashed on one side of the wall but they look at it anyway because they can’t resist
Define Frontal apraxia
Not being able to follow steps in routine tasks (e.g. making tea)
Repeating the same action when it is no longer relevant
Which brain lesion does the above statement apply to?
a. Frontal apraxia
b. Perseveration
c. Utilisation behaviour
d. Disinhibition
b. Perseveration
When the person acts on an irrelevant (or inappropriate) object in environment
Which brain lesion does the above statement apply to?
a. Frontal apraxia
b. Perseveration
c. Utilisation behaviour
d. Disinhibition
c. Utilisation behaviour
e.g. Visiting your neurologist and putting on their glasses, inappropriate social behaviour
Which brain lesion does the above statement apply to?
a. Frontal apraxia
b. Perseveration
c. Utilisation behaviour
d. Disinhibition
c. Utilisation behaviour
The inability to withhold an inappropriate or unwanted behaviour
Which brain lesion does the above statement apply to?
a. Frontal apraxia
b. Perseveration
c. Utilisation behaviour
d. Disinhibition
d. Disinhibition
e.g. antisaccade task
Person is asked to not look at the light flashed on one side of the wall but they look at it anyway because they can’t resist
Which brain lesion does the above statement apply to?
a. Frontal apraxia
b. Perseveration
c. Utilisation behaviour
d. Disinhibition
d. Disinhibition
Not being able to follow steps in routine tasks (e.g. making tea)
Which brain lesion does the above statement apply to?
a. Frontal apraxia
b. Perseveration
c. Utilisation behaviour
d. Disinhibition
a. Frontal apraxia
Perseveration is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Frontal apraxia is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Hemiplegia is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
Disinhibition is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Hemiparesis is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
Utilisation behaviour is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
a. Prefrontal cortex
Stroke affecting one side
of the brain is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
c. Primary Motor Cortex
Describe Antisaccades
List 2 points
- Required to look in opposite direction to the target
- Must inhibit (pre-potent) tendency to look at target
- Required to look in opposite direction to the target
- Must inhibit (pre-potent) tendency to look at target
This is known as…?
Antisaccades
In Antisaccades, participants are required to look in the opposite direction to the target
What must they inhibit?
Must inhibit (pre-potent) tendency to look at target
Describe the 2 components of the Normal and Shallice model?
- Contention scheduling
- Supervisory attentional System (SAS)
- Contention scheduling
- Supervisory attentional System (SAS)
These are the 2 components of…?
Normal and Shallice model
What is the role of contention scheduling in the Normal and Shallice model?
Selects appropriate schema/actions at the appropriate time
What is the role of the Supervisory attentional System (SAS) in the Normal and Shallice model?
Required for novel/less automatic actions or when you need to perform something different
Selects appropriate schema/actions at the appropriate time
a. Contention scheduling
b. Supervisory attentional System (SAS)
a. Contention scheduling
Required for novel/less automatic actions or when you need to perform something different
a. Contention scheduling
b. Supervisory attentional System (SAS)
b. Supervisory attentional System (SAS)
How can we explain action errors from prefrontal cortex damage?
- Perseveration: unable to change schemas when it is no longer appropriate
- Utilisation behaviour: schemas are activated by the environment without the SAS suppressing them
How can we explain action errors from prefrontal cortex damage such as perseveration?
We are unable to change schemas when it is no longer appropriate
How can we explain action errors from prefrontal cortex damage such as utilisation behaviour?
Schemas are activated by the environment without the SAS suppressing them
True or False?
We all make action errors but people with cognitive lesions are more prone to these errors
True
Apraxia is a lesion involved in which region of the brain?
a. Prefrontal cortex
b. Parietal cortex
c. Primary Motor Cortex
d. Premotor cortex
b. Parietal cortex
Damage to the parietal
cortex can lead to …?
Apraxia
Define Apraxia
Inability to perform skilled
purposeful movement
Inability to perform skilled
purposeful movement
This is known as…?
Apraxia
How can parietal cortex be useful for understanding movements?
Knowing where things are (spatial information)
Define Ideomotor Apraxia
When idea and execution are disconnected but we retain knowledge of action
When idea and execution are disconnected but we retain knowledge of action
This is known as…?
Ideomotor Apraxia
Can recognise action performed by another
a. Ideomotor Apraxia
b. Apraxia
c. Frontal Apraxia
d. Utilisation behaviour
a. Ideomotor Apraxia
Fail in pantomiming action (e.g. using body part as tool)
a. Ideomotor Apraxia
b. Apraxia
c. Frontal Apraxia
d. Utilisation behaviour
a. Ideomotor Apraxia
Can perform sequence but not components
a. Ideomotor Apraxia
b. Apraxia
c. Frontal Apraxia
d. Utilisation behaviour
a. Ideomotor Apraxia
What are the 3 characteristics of Ideomotor Apraxia?
- Can recognise action performed by another
- Fail in pantomiming action (e.g. body part as
tool)
simply = fail to mime simple everyday actions
e.g. Using your index finder as a toothbrush when miming the action of brushing your teeth instead of miming a hand grabbing action of the toothbrush
- Can perform sequence but not components
- Do not have a meaning for the action
Fail to mime simple everyday actions
e.g. Using your index finder as a toothbrush when miming the action of brushing your teeth instead of miming a hand grabbing action of the toothbrush
What type of lesion does this apply to?
a. Ideomotor Apraxia
b. Apraxia
c. Frontal Apraxia
d. Utilisation behaviour
a. Ideomotor Apraxia
What are the 2 Subcortical Motor Areas?
- Basal Ganglia (nuclei of the mid-brain)
- Cerebellum (back of the brain)
Cerebellum lesion is referred to as…?
Cerebellar
What is Cerebellar?
Cerebellum lesion
What can Cerebellar patients experience?
List 5 points
- Action tremor
- Dysmetria: over and undershooting of movements
- Deficits in coordinating across joints
- Deficits in motor learning
- Deficits in timing
What brain lesion does this symptom apply to?
Action tremor
Cerebellar
What brain lesion does this symptom apply to?
Dysmetria: over and undershooting of movements
Cerebellar
What brain lesion does this symptom apply to?
Deficits in coordinating across joints
Cerebellar
What brain lesion does this symptom apply to?
Deficits in motor learning
Cerebellar
What brain lesion does this symptom apply to?
Deficits in timing
Cerebellar
Define Dysmetria
Over and undershooting of
movements
Simply = Reaching out too far past an object or reaching out too short of an object
Over and undershooting of
movements
Simply = Reaching out too far past an object or reaching out too short of an object
This is known as…?
Dysmetria
What brain lesion does this symptom apply to?
Deficit in predicting the outcome of movements
Cerebellar
Describe the Random Saccade Test
Participants are asked to follow where the instructor’s fingers move (eyemovement test)
Describe results of the Random Saccade Test with Cerebellar patients
Patients overshot the movements of the instructor’s fingers
Describe the results of the finger to nose movement in patients with cerebellar tremor
The tremor amplitude increases as the finger nears the target
Describe the results of the finger to nose movement in patients with Parkinson’s disease
The tremor may be present at the beginning of the movement (not making any action) and smooth out near the nose
Describe the results of the finger to nose movement in patients with essential tremor
The tremor exists throughout the test, possibly worsening as the finger approaches the nose
The tremor exists throughout the test, possibly worsening as the finger approaches the nose
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
a. Essential tremor
The tremor may be present at the beginning of the movement (not making any action) and smooth out near the nose
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
The tremor amplitude increases as the finger nears the target
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
d. Cerebellar tremor
How common is Parkinson’s disease?
1 in 1000 people
How common is Parkinson’s disease in people over 65?
1 in 100 people over 65
What are the 4 movement symptoms of Parkinson’s disease?
- Bradykinesia – slow movement
- Tremor (resting)
- Rigidity
- Shuffling their feet
Define Bradykinesia
Slow movement
Define resting tremor
Tremor that is not always present
Define rigidity
Inability to relax (e.g. their arm), muscle is stiff
What causes shuffling (small footsteps) in people with Parkinson’s disease?
Death of dopaminergic cells in substantia nigra pars compacta
Death of dopaminergic cells in substantia nigra pars compacta causes ____
Shuffling in Parkinson’s disease
How can people with Parkinson’s disease improve shuffling, arms not swinging properly and difficulty turning their body (improve movement)?
Taking dopamine medication
Bradykinesia – slow movement
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
Resting tremor
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
Rigidity
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
Shuffling, arms not swinging properly and difficulty turning their body
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
What does writing with Parkinson’s disease look like?
List 2 points
- Small in size
- May reduce in size while writing (due to fatigue)
Writing is small in size
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
Writing may reduce in size while writing due to fatigue
a. Essential tremor
b. Parkinson’s disease
c. No pathological temor
d. Cerebellar tremor
b. Parkinson’s disease
What are the 3 deficits of Parkinson’s disease?
- Internal/external
- More problems with
internally generated movements
- Complex movements
- Bimanual, sequences of movements
- Cognitive effects
- Attention shifting,
everyday cognitive failures
Patients with Parkinson’s disease experience more problems with _____ generated movements
a. Internal
b. External
a. Internal
Patients with Parkinson’s disease experience deficits in complex movements
What are the 2 complex movements they struggle with?
- Bimanual tasks
- Sequences
Patients with Parkinson’s disease experience deficits in cognitive effects
What are the 2 cognitive effects they struggle with?
- Attention shifting
- Everyday cognitive failures