Morphology and Histology Flashcards
What structures lie adjacent to the pituitary gland?
Trochlear nerve Internal Carotid a Oculomotor n Optic tracts (Ant/Sup) Trigeminal n Abducens n
What structure is most compressed by a Pit. Adenoma?
Internal Carotid a
Cranial nerve palsies
What BVs supply the anterior Cortical Border Zone
Internal Border zone?
posterior Cortical Border Zone
ACA and MCA
ACA and MCA
MCA and PCA
What is the significance of empty sella syndrome?
A defect in the sellar diaphragm
Arachnoid mater gets pushed into the sella turcica and it compresses on the pituitary
Primary: asymptomatic
Secondary: symptomatic
What is the collar of tissue that encompasses the infundibulum?
Pars tuberalis
What are the tissue types in the anterior/posterior Pit?
Ant: Pars Tuberalis, Intermedia, distalis
Post: Infundibular stalk
Pars Nervosa
What embryological tissue leads to the anterior pit? Posterior?
oral Ectoderm > Rathke’s pouch > anterior lobe > neuroectoderm > posterior lobe
What are the signaling molecules involved in devt of the Pituitary gland?
Bone morphogenic protein-4 and Fibroblast growth factor8
BMP-4 and FGF-8
What makes up a craniopharyngioma?
Remnants of Rathke’s cleft and craniopharyngeal duct in children
Adult devt from mature cells in anterior hypophysis
What is the bood supply to the Ant/post pituitary?
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What is the histology of a pituitary adenoma?
Posesses a scant reticulin network
What happens to bone growth when IGF-1 is absent?
Proliferative zone is expanded and hypertrophic zone is decreased
What cell type produce prolactin?
acidophils
What cell types produce gonadotropins?
Basophilic granules
What cell types are found in the Mucoid wedge?
Lateral wings?
ACTH and TSH producing cells
PRL and GH producing cells
