Hypersecretory Ant-Pituitary Flashcards
What are the 6 Anterior Pituitary Hormones?
Thyroglobulin: TSH (vital) Corticotropin: ACTH (vital) Gonadotropins: FSH and LH Prolactin: PL Growth Hormone: GH
WHat are the 2 hormones secreted by the posterior Pituitary?
Arginine Vasopressin
Oxytocin
What is Sheehan’s Postpartum Necrosis?
Increased size of Pituitary combined with hypoperfusion post partum (bleeding, etc) causes an infarct of the pituitary.
What diseases can effect multiple systems with diverse symptoms.
Hemochromatosis
Amyloidosis
Sarcoidosis
WHich hormones lack simple end organ feedback inhibitory loops?
Prolactin
Growth Hormone
What are the effects of Large pituitary Tumors?
Hypopituitarism
Neuro Disturbances
-Visual Field(optic Chiasm)
What are effects of Hypogonadism?
W: irregular menses, infertility, osteoporosis
M: Impotence, infertility
What drugs can cause Hyperprolactinemia?
Verapamil
Haldol
Risperdone
Metoclopramide
Who is most commonly effected by prolatinomas?
Smaller tumors more commonly in Women. They come in earlier
Larger tumors more common in males. Wait longer to come in
What is the Tx of Prolactinoma?
Bromocriptine
What are the signs of hypoprolactinemia
Failure to lactate
Cause: Sheehan Synd
Must do stimulation test with TRH or chlopromazine
What are the syndromes of GH Excess?
Giagantism: before ephiphyseal closure in peds
Acromegaly: insidious, chronic, debilitating. Associated with bony and soft tissue overgrowth
M: CV, resp
F: Cerebrovasc, resp
How is GH excess diagnosed?
GH inhibition test
Glucose challenge
What are common causes of GH excess?
Adenoma
Primary Pituitary problem
Rare GRH induced
ectopic?
Where is the Problem in Cushing’s disease? Synd?
Hypothalamus
Synd is all over.
