Morphine

Question 1

Morphine
Classification

Answer 1

Opiate Analgesic

Question 2

Morphine
Mechanism of Action

Answer 2

Opiate R agonist-hyperpolarization of interneurons and decreased release of neurotransmitters responsible for the transmission of pain impulses to the thalama and cerebral cortex

Question 3

Morphine
Onset of Action

Answer 3

Immediate IV
15-30 min IM

Question 4

Morphine
Peak Effects

Answer 4

20 min IV
30-60 min IM

Question 5

Morphine
Duration of Effect

Answer 5

2-7 hrs

Question 6

Morphine
Half-life

Answer 6

1-7 hrs

Question 7

Morphine
Indications/Field Use

Answer 7

Pain management

Question 8

Morphine
Contraindications

Answer 8

Hypotension
Significant head trauma with AMS

Question 9

Morphine
Side Effects/Adverse Reactions

Answer 9

N/V
Abdominal cramps
Blurred vision
Constricted pupils
AMS
HA

Question 10

Morphine
Adult Dose

Answer 10

0.1mg/kg IV/IO/IM (single max dose 10mg), may repeat q 5 min to total of 20mg, titrated to pain relief and if systolic BP is >100mmHg

Question 11

Morphine
Pedi Dose

Answer 11

0.1mg/kg IV/IO (single max dose 5mg), may repeat 0.05mg/kg (single max dose 2.5mg) q 5 min to total of 3 doses

Question 12

Morphine
Precautions

Answer 12

-Morphine causes reduced chemoreceptor responsiveness to increases in CO2 which may lead to respiratory depression
-Caution with patient with hypersensitivity to analogs of mophine

Question 13

Morphine
Drug-drug interactions

Answer 13

Additive effects (CNS depression) when given with antihistamines, antiemetics, sedatives, hypnotics, barbiturates, and alcohol