morph Flashcards
- Lacks high grade nuclei or central necrosis.
* Micropapillary pattern: Bulbous protrusions w/t fibrovascular core in complex intraductal patterns.
noncomedo DCIS
signet ring cess w intracytoplasmic mucin droplets
lobular carcinoma
fibromatosis
clonal proliferation of fibroblasts and myofibroblasts
mucin + signet ring cells
LCIS
o Ectatic dilated ducts w inspissated secretions and lipid laden Mfs.
o Rupture → periductal and interstitial inflamm. rxn w lymphocytes and plasma cells also joining the party.
o granulomas around cholesterol deposits & secretions
duct ectasia
~ sweat glands.
enlarged round nuclei w prominent nucleoli and lots of eos or granular cyto
apocrine carcinoma
- Thick BM of atrophic ducts & lobules.
* Surrounded by prominent lymphocytic infiltrate
Lymphocytic Mastopathy (sclerosing lymphocytic lobulitis)
- clusters/linear//branching areas of calcification
- pleomorphic high grade nuclei
- central necrosis
comedo DCIS
neutrophils + Mfs in breast tissue
acute fat necrosis of breast
Mimics lactating breasts by forming dilated spaces filled with eosinophilic material.
secretory carcinoma
- Lacks high grade nuclei or central necrosis.
* Cribiform pattern: Rounded spaces within ducts (cookie cutter) or solid pattern
noncomedo DCIS
- well diff
- mucinous, papillary, cribiform or lobular patterns
ER(+), HER2(-), high Proliferation Invasive (infiltrating) Carcinoma
rounded cells not attached to adjacent cells (discohesive)
LCIS (bc lack e cadherin)
hollow balls of cells that float within intercellular fluid creating structures that mimic the appearance of true papillae
micropapillary carcinoma
Consists exclusively of well-formed tubules.
Cribiform pattern maybe
Apocrine snouts
Calcifications may be seen in the lumens.
tubular carcinoma
Soft or rubbery and has pale gray-blue gelatin appearance.
Borders are pushing or circumscribed.
Cells are clustered in small islands within large mucin lakes.
Mucinous (colloid) Carcinoma
Dense collagenous CT and ductal epithelail hyperplasia (no lobule formation)
male breast cancer
contain turbid, semi transluscent brown-blue fluid (blue domed cyst).
Lined with flattened, atrophic epi or metaplastic apocrine cells.
cysts: nonproliferative breast change
- leaf-like
- Larger lesions have bulbous protrusions d/t nodules of proliferating stroma covered by epi.
- Higher cellularity, mitotic rate, nuclear pleomorphism, stromal overgrowth, infiltrative borders
phyllodes tumor (cystosarcoma)
- Lacks high grade nuclei or central necrosis.
* True papillae pattern: Fibrovascular core w/o myoepi cell layer.
noncomedo DCIS
- poorly diff
- fibrotic or necrotic center
- -lymphocytic infiltrate
- basal keratins
ER(-), HER2(-) Invasive (infiltrating) Carcinoma
cluster of lg cells w pale cytoplasm containing MPS
paget dis of nipple
fat containing lesions
lipoma
fibroblasts and inflamm. cells lead to giant cells, calcifiations & deposition of hemosiderin → scar tissue.
chronic fat necrosis of breast
“indian file” infiltration
lobular carcinoma
ill-defined, firm, grey-white nodules containing small chalky white foci
scar tissue from fat necrosis of the breast
o Keratinizing squamous metaplasia of the nipple ducts.
o Ductal system is plugged by shed cells → dilation & eventually rupture of the duct.
o Keratin spills into the surrounding periductal tissue → intense chronic granulomatous response.
o Acute inflamm. may occur secondary to anaerobic bacterial infxn.
Squamous Metaplasia of Lactiferous Ducts
• AKA: Subaerolar abscess, Periductal mastitis, or Zuska dz.
- poorly diff
- apocrine or micropapillary
- extensive DCIS
HER+ Invasive (infiltrating) Carcinoma
o Well-cicumscribed, rubbery, greyish-white nodules that bulge above the surrounding tissue and contain slit-like spaces
o In older women, the stroma typically becomes densely hyalinized and the epi atrophic.
fibroadenoma
Soft d/t minimal desmoplasia.
well circumscribed mass.
Solid, syncytium sheets of lg cells w lg, pleomorphic nuclei, prominent nucleoli (75% of tumor mass)
Frequent mitotic figures.
Lymphoplasmacytic infiltrate surrounding & within the tumor.
Pushing (noninfiltratitve) border
medullary carcinoma
true papilla: Fronds of fibrovascular tissue lined by tumor cells
papillary carcinoma
