Mood Disorders Flashcards
Borod
Major models on emotion. RH specialised in emotion processing OR Valence hypothesis (RH dominant for -ve, LH for +ve emotions)
Test hemispheric differences
Show words to R or L vf and test recall. Emotional word presented to R or L vf, can recall either. Trivial word easier to recall on R vf. Supports LH = language, RH = emotions?
Maletic et al
Network between executive cortex and limbic formations = interrupted so receives less control feedback
Price and Drevets
Dysfunction within network inc. medial prefrontal cortex and limbic, striatal, thalamic and basal forebrain structures
Belzung et al
Altered function of prefrontal areas and cingulate cortex, amygdala, lateral habenula and hippocampus. Dysfunction in each of these areas responsible for specific depression symptom?
Garcia-Toro et al
Depression improved when high frequency TMS over L PFC. Mania improved when high frequency TMS over R PFC. SO both hemispheres involved?
Huffman and Stern
4 case studies and not all consistent with Garcia-Toro et al’s idea
Carson et al
Meta-analysis supports Huffman and Stern. No association between brain infarct location and depression.
Sperli et al
DBS pre-operation in epileptic patient. Stimulate R cingulate gyrus = smile and laugh but not amused SO motor response veridical
Okun et al
PD patient = DBS R globus pallidus = facial pulling, discomfort, agitation
OCD patients = DBS L globus pallidus = smile BUT does this = pleasure?
Vataja et al
70 patients with single infarct. Post-stroke depression = dominance of LH lesions and in basal ganglia structures SO side and site important
Mimura et al
Depression case study (F, 78 yrs). Post-stroke = mania and L fronto-temporal hyperperfusion BUT no more depression
