Monocyte-Macrophage Series

Question 1

Name the three major cell types found in the RES

Answer 1

Reticulum cells
Endothelial cells
Free macrophages (or histiocytes)

Question 2

Lives 5 general functions of the RES

Answer 2

Phagocytosis
Humoral defense
Hematopoiesis
Storage
Metabolism

Question 3

Describe the two major functions of the macrophage

Answer 3

Phagocytosis to clear up organisms and remove damaged/senescent cells
Participation in the immune response by trapping Ag and processing them into more antigenic form stimulating Ab production

Question 4

Describe the nuclear and cytoplasmic appearance of the monoblast

Answer 4

N: round to oval (or irregularly shaped) w/ fine chromatin; no presence of granules
C: light blue to gray in color

Question 5

Describe the nuclear and cytoplasmic appearance of the promonocyte

Answer 5

N: irregularly shaped, folded, brainlike convolutions w/ fine to lacy chromatin; fine, burgundy colored granules
C: light blue to gray in color

Question 6

Describe the nuclear and cytoplasmic appearance of the monocyte

Answer 6

N: variable (round, horseshoe, kidney bean) w/ foldes producing brainlike convolutions w/ lacy chromatin; granules giving appearance of ground glass
C: blue-gray in color, may have pseudopods

Question 7

Describe the nuclear and cytoplasmic appearance of the macrophage

Answer 7

N: eccentric, kidney or egg-shaped, indented, or elongated w/ fine, dispersed chromatin; numerous burgundy colored granules
C: irregular borders; may contain ingested material

Question 8

Describe the two major functions of the macrophage

Answer 8

1. Phagocytosis → clearance of organisms and removal of damaged/senescent cells
2. Participation in the immune response → trap Ags and proccess them into more antigenic form which stimulates Ab production