Monocyte-Macrophage Series

Question 1

A Complex System- Essential for Body Defense

Answer 1

Reticuloendothelial System (RES)

Question 2

Name the Three Major Cell Types Found in RES, and the Organs in Which They are Seen

Answer 2

1. Reticulum Cells
   - Spleen, Lymph Nodes, and Bone Marrow
2. Endothelial Cells
   - Spleen, Lymph Nodes, Bone Marrow, and Liver
3. Free Macrophages (or Histiocytes)
   - Spleen, Bone Marrow, and Lungs

Question 3

Name the Five General Functions of the RES

Answer 3

1. Phagocytosis
2. Humoral Defense
3. Hematopoieisis
4. Storage
5. Metabolism

Question 4

Name the Monocyte:

12-18 microns; Light Blue to Grey Cytoplasm; Round to Oval Nucleus, may be irregularly shaped

Answer 4

Monoblast

Question 5

Name the Monocyte:

12-20 microns; Light Blue to Grey Cytoplasm; Irregularly Shaped Nucleus, May have brain-like convolutions

Answer 5

Promonocyte

Question 6

Name the Monocyte:
12-20 microns; Blue-Grey Cytoplasm, may have pseudopods; Variable Nucleus, may be round, horseshoe-shaped, or kidney shaped/often has folds producing brain-like convolutions

Answer 6

Monocyte

Question 7

Named the Monocyte:
15-80 microns; Cytoplasm is abundant with irregular borders, may contain ingested material; Eccentric, kidney or egg-shaped nucleus/indented, or elongnated

Answer 7

Macrophage (Histiocyte)

Question 8

What are the Two Major Functions of Macrophages

Answer 8

1. Phagocytosis
   - Clearance of organisms
   - Removal of damaged/senescent cells
2. Participation in the Immune Response
   - Trapping Antigen and processing into a more antigenic form… which stimulates Antibody production