Granulocyte Series Flashcards
Name the six maturation stages of the neutrophilic cell series beginning with the myeloblast:
Myeloblast; Promyelocyte; Myelocyte; Metamyelocyte; Band Neutrophil; Polymorphonuclear Neutrophil/Segmented Neutrophil
Name the Neutrophil;
15-20 microns, Round to Oval nucleus (2-5 nucleoli)/Fine chromatin, Moderate basophilia cytoplasm
Myeloblast
Name the Neutrophil;
14-20 microns, Round to Oval nucleus (1-3 nucleoli)/Slightly coarser chromatin, Basophilic cytoplasm
Promyelocyte
Name the Neutroplhil;
12-18 microns, Round to oval nucleus (may have one flatten side, nucleoli usually not visible)/ Coarser and more condensed Chromatin, Slightly basophilic cytoplasm (may be clear area close to the nucleus)
Myelocyte
Name the Neutrophil;
10-15 microns, Indented kidney bean shaped nucleus/Coarsely clumped chromatin, Pale blue to pink cytoplasm
Metamyelocyte
Name the Neutrophil;
10-15 microns, Nucleus C or S shaped but no threadlike filament/Chromatin must be visible in the filament, Coarsely clumped Chromatin, Pale blue to pink cytoplasm
Band Neutrophil (Band)
10-15 microns, Nucleus is 2-5 lobes connected by thin filaments without visible chromatin, Coarsely clumped chromatin, Pale blue to pink cytoplasm
Polymorphonuclear Neutrophil (Poly, PMN) Segmented Neutrophil (Seg)
Explain Non-specific Granules
- First Degree
- Appear at the Promyelocyte Stage (B)
- Rich in Peroxidase
Explain Specific Granules
- Second Degree
- Appear at the Myelocyte Stage (C, G, K)
- Rich in LAP (Leukocyte Akaline Phosphatase)
Name the Three Compartments in Which Granulocytes are Found Within the Body:
- Bone Marrow
- Peripheral Blood (Circulation)
- Tissue
Discuss Granulocyte Kinetics In Terms of;
-(Approximate) Time present
-Maturation stage of cells
BONE MARROW
-Mitotic Pool
3-6 days
Myeloblast, Promyelocyte, Myelocyte
-Post-Mitotic Pool
5-7 days
Metamyelocyte, Band, Seg
Discuss Granulocyte Kinetics In Terms of;
-(Approximate) Time present
PERIPHERAL BLOOD
-10 Hours of Circulation
MGP: Marginating Granule Pool (Goes out in capillaries)
CGP: Circulating Granule Pool
Discuss Granulocyte Kinetics In Terms of;
-(Approximate) Time present
TISSUE
-4-5 Days
What is the Bone Marrow’s Two Responses to an Increase in Demand for Granulocytes in the Tissues? (Regulatory Mechanism)
- Migration from the storage pool to the peripheral blood (“Shift to the Left”/left shift)
- Increased Production (Increased WBC Count)
What are the Four Stages of Phagocytosis?
- Adherence- Opsonization
- Ingestion- Phagocytic Vacuole
- Degranulation- Phagocytic Vacuole
- Exocytosis
Name the Major Function of Basophils
Granules contain the majority of the body’s:
-Histamine
-Heparin; or heparin-like substances
Increased in:
-(some) malignant disorders- CML (Chronic Myologenous Leukemia)
Name the Major Function of Eosinophils
-Aggregate at site of Antigen/Antibody complexes… and phagocytize these complexes
Increased in;
-Allergic reactions
-Parasite infections
Name the Major Function of Neutrophils
- Leave vasculature and migrate to areas of tissue damage or infection, mainly bacterial
- Phagocytosis occurs
“Production of Granulocytes”; Takes place in Bone Marrow (Red Marrow) between sinusoids…
Myelopoiesis
The process by which a cell engulfs a solid particle to form an internal vesicle known as a phagosome.
Phagocytosis
A phrase used to note that there are a high number of young, immature white blood cells present.
“Shift to the Left” (Left Shift)
