monocyte/macrophage abnormalities

Question 1

Are macrophages with lipofuscin, glycophospholipid, and sphingomyelin contained in cytoplasmic granules, 1 to 3 um in diameter, that appear blue with Wright stain

Answer 1

sea-blue histiocytes

Question 2

• Macrophages with cytoplasm packed with lipid filled lysosomes that appear as small vacuoles (foam) after staining
• Niemann-Pick’s disease

Answer 2

foam cell

Question 3

• are distinctive macrophages, single or in clusters; “CRUMPLED TISSUE APPERANCE”
• Abundant fibrillar blue-gray cytoplasm with a striated or wrinkled appearance (sometimes described as onion skin-like)
• Positive with trichrome, aldehyde fuchsin, periodic acid-Schiff (PAS) and acid phosphatase

Answer 3

gaucher cell