granulocyte nuclear abnormalities

Question 1

Normal neutrophils contain (?) lobes that are separated by filaments

Answer 1

three to five

Question 2

• Usually a neutrophil that has ingested the antibody coated nucleus of another neutrophil or has engulf the homogenous, globular nuclear mass of destroyed cell
• Presence of: ANTI-NUCLEAR ANTIBODIES, cell nuclei, phagocytes with ingested material
• Usually mistaken with a tart cell (monocyte with an ingested lymphocyte)

Answer 2

LE cell

Question 3

• Megaloblastic anemia
• Undritz anomaly
• Myelodysplasia

Answer 3

hypersegmentation/hypersegmented neutrophils

Question 4

• Round, ovoid (Homozygous Pelger-Huet)
• Bilobed forms the characteristic spectacle-like (“pince-nez”, dumbbell, peanut) morphology with the nuclei attached by a thin filament (Heterozyous Pelger-Huet)

Answer 4

hyposegmented neutrophils

Question 5

• Pelger-Huet anomaly
• Pseudo or Acquired Pelger-Huet anomaly
• Myelodysplastic syndrome
• Acute myeloid leukemia
• Myeloproliferative neoplasms

Answer 5

hyposegmented neutrophils

Question 6

Hypersegmented neutrophils have (?) lobes and are usually larger than normal neutrophils

Answer 6

more than five

Question 7

• Systemic Lupus Erythematosus
• Connective tissue disorders

Answer 7

LE cell

Question 8

• Represents the 2nd X chromosome in females
• Seen in 2-3% of neutrophils
• Characteristic “DRUMSTICK” appearance of neutrophils

Answer 8

barr body