Monoclonal antibodies Flashcards
Against CD20 molecule on B cell
Zevalin
Targets CD20
Treat B cell lymphomas
(non Hodgkin’s) cancer of lymphoid tissues
Lymph nodes, spleen
Rituximab
Conjugate of MAb against CD20
Tositumomab
Conjugate of MAb that binds to CD30 (expressed by cells of some lymphomas
Not found on normal cells
Adcetris
Drug blocks mitosis
Vedotin
Binds to CD22
Found on B cell leukemias
LymphoCide
Targets ag CD52 on T and B cells
Produced complete remission of chronic lymphocytic leukemia, B cell leukemia
Alemtuzumab
Acts to enhance body’s own immune response tot tumors
Ipilimumab
Acute myeloid leukemia
Targets surface Ag CD33 on leukemia cells
Gemtuzumab
Anti-angiogenic cancer therapy
Colorectal and breast CA
Inhibits VEGF
Bevacizumab
Breast cancer
Targets receptor erbB2
Trastuzumab
Colorectal CA and squamous cell CA
EGFR inhibitor
Cetuximab
Squamous cell CA
EGFR inhibitor
Nimotuzumab
RSV infections
Inhibits RSV F protein
Palivizumab
Prevent coagulation in coronary angiolasty
Inhibits receptor on platelets
Abciximab
With two humanized antiCD3
Bind to CD3 molecule of T cells
Prevent acute rejection of organ
Muromonab-CD3
Inhibits tumor necrosis factor alpha
RA, crohn’s dse, Ulcerative colitis
Inflixmab
Adalimumab
Inhibits IgE
Moderate to severe allergic asthma
Omalizumab
Inhibits IL2 receptor on activated T cells
Used to prevent acute rejection o transplanted kidneys
Against T cell lymphoma
Daclizumab
Basiliximab
MAbs that suppress immune system
Muromonab-CD3
Inflixmab & adalimumab
Omalizumab
Daclizumab & basiliximab
Mabs conjugated with toxin to target cancer cells
Immunotxins
Genetically modified micr that produce Ab with a human constant tegion
Chimeric MAbs
Mabs that are mostly himan except for mouse antigen-binding
Humanized mabs
Mabs produced from a human gene on a mouse
Fully human antibodies
Magic bullet in biomedicine
Monoclonal antobodies
Anticancer and antiviral
Target: phospatidyl serine
Bavituximab
