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Immunoserology > Monoclonal antibodies > Flashcards

Monoclonal antibodies Flashcards

0
Q

Against CD20 molecule on B cell

A

Zevalin

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1
Q

Targets CD20
Treat B cell lymphomas
(non Hodgkin’s) cancer of lymphoid tissues
Lymph nodes, spleen

A

Rituximab

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2
Q

Conjugate of MAb against CD20

A

Tositumomab

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3
Q

Conjugate of MAb that binds to CD30 (expressed by cells of some lymphomas
Not found on normal cells

A

Adcetris

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4
Q

Drug blocks mitosis

A

Vedotin

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5
Q

Binds to CD22

Found on B cell leukemias

A

LymphoCide

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6
Q

Targets ag CD52 on T and B cells

Produced complete remission of chronic lymphocytic leukemia, B cell leukemia

A

Alemtuzumab

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7
Q

Acts to enhance body’s own immune response tot tumors

A

Ipilimumab

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8
Q

Acute myeloid leukemia

Targets surface Ag CD33 on leukemia cells

A

Gemtuzumab

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9
Q

Anti-angiogenic cancer therapy
Colorectal and breast CA
Inhibits VEGF

A

Bevacizumab

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10
Q

Breast cancer

Targets receptor erbB2

A

Trastuzumab

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11
Q

Colorectal CA and squamous cell CA

EGFR inhibitor

A

Cetuximab

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12
Q

Squamous cell CA

EGFR inhibitor

A

Nimotuzumab

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13
Q

RSV infections

Inhibits RSV F protein

A

Palivizumab

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14
Q

Prevent coagulation in coronary angiolasty

Inhibits receptor on platelets

A

Abciximab

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15
Q

With two humanized antiCD3
Bind to CD3 molecule of T cells
Prevent acute rejection of organ

A

Muromonab-CD3

16
Q

Inhibits tumor necrosis factor alpha

RA, crohn’s dse, Ulcerative colitis

A

Inflixmab

Adalimumab

17
Q

Inhibits IgE

Moderate to severe allergic asthma

A

Omalizumab

18
Q

Inhibits IL2 receptor on activated T cells
Used to prevent acute rejection o transplanted kidneys
Against T cell lymphoma

A

Daclizumab

Basiliximab

19
Q

MAbs that suppress immune system

A

Muromonab-CD3
Inflixmab & adalimumab
Omalizumab
Daclizumab & basiliximab

20
Q

Mabs conjugated with toxin to target cancer cells

A

Immunotxins

21
Q

Genetically modified micr that produce Ab with a human constant tegion

A

Chimeric MAbs

22
Q

Mabs that are mostly himan except for mouse antigen-binding

A

Humanized mabs

23
Q

Mabs produced from a human gene on a mouse

A

Fully human antibodies

24
Q

Magic bullet in biomedicine

A

Monoclonal antobodies

25
Q

Anticancer and antiviral

Target: phospatidyl serine

A

Bavituximab

Immunoserology (3 decks)

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