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immunoserology > Complement Pathway > Flashcards

Complement Pathway Flashcards

0
Q

Cleaves c1s to activate protease function

A

C1r

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1
Q

Binds to antibody that has bound antigen, activates C1r

A

C1q

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2
Q

Cleaves C2 and C4

A

C1s

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3
Q

Unknown function

A

C2a

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4
Q

Activate enzyme of classical pathway

Cleaves C3 and C5

A

C2b

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5
Q

Mediates inflammation

Anaphylatoxin

A

C3a

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6
Q

Binds c5 for cleavage of C2b

Binds cell surfaces for opsonization and activation of alternate pathway

A

C3b

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7
Q

Mediates inflammation

A

C4a

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8
Q

Binds C2 for cleavage by C1s

Bids cell surfaces for opsonization

A

C4b

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9
Q

Mediates inflammation, anaphylotoxin, chemotaxin

A

C5a

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10
Q

Initiates assembly of the membrane attack complex

A

C5b

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11
Q

Binds c5b

Forms receptor for c7

A

C6

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12
Q

Binds c5b6, inserts into membrane, forms acceptor for c8

A

C7

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13
Q

Binds c5b67

Initiates c9 polynerization

A

C8

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14
Q

Polymerizes around c5b678 to form channel that causes cell lysis

A

C9m

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15
Q

Alt Path
Mediates inflammation
Anaphylotoxin

A

C3a

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16
Q

Alt Path

Binds cell surfaces for opsonization and activation of alternate pathway

A

C3b

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17
Q

Alt Path
Bids membrane bound c3b
Cleaved by factor D

A

Factor B-B

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18
Q

Alt Path

Unknown

A

Factor B-Ba

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19
Q

Alt Path

Cleaved form stabilized by P produces c3 convertase

A

Factor B-Bb

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20
Q

Cleaves factor B when bound to c3b

Alt Path

A

Factor D

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21
Q

Binds and stabilizes membrane bound c3bBb

Alt Path

A

Properdin-P

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22
Q

Cleave C2 and C5

Lectin Pathway

A

MASP

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23
Q

Lectin pathway or

A

Mannose binding lectin pathway

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24
Q

Activates C1s

A

C1r

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25
Q

Binds to fc region of IgM and IgG

A

C1q

26
Q

MASP

Cleaves c4 and c2

A

MASP 2

27
Q

Central molecule of complement cascade

A

C3b

28
Q

C3b functions

A

Opsonizes bacteria

Combines with other complement to generate c5 convertase

29
Q

For opsonization

Enhance phagocytosis

A

C3b

C1q

30
Q

For chemotaxis

Attracts neutrophils

A

C5a

C5, 6, 7 complex

31
Q

Enhance adhesiveness of neutrophils to endothelium

A

C5a

32
Q

Serves as chemoattractants for chemotaxis

A

C5a

33
Q

Anaphylotoxin

A

Mast cell

Basophils

34
Q

One of the agents that induces vascular permeability

A

Histamine

35
Q

Disrupt membrane and entry of water and electrolytes into the cell

A

Cytolysis MAC

36
Q

Binding of c3b to its receptors on the surface of activated B cells

A

Enhance ab production

37
Q

Important regulator of classical pathway

A

C1 INH

38
Q

Serine protease inhibitor/serpin

A

C1 INH

39
Q

Irreversibly binds to and inactivates c1r and c1s as well as MASP in lectin pathway

A

C1 INH

40
Q

Regulates alternative pathway

A

Factor H

41
Q

Reduces amount of c5 convertase available

A

Factor H

42
Q

Protects c3b and stabilizes c3 convertase

A

Properdin

43
Q

Cleaves cell bound or fluid phase c3b and c4b

Inactivates c3b and c4b

A

Factor I

44
Q

Glycoprotein on surface human cells

A

DAF

45
Q

Prevents assembly of c3bBb or accelerates disassembly of preformed convertase

A

DAF

46
Q

Cofactor of Factor I

A

C4b binding protein

C4BP

47
Q

Inhibits the action of c4b in classical pathway

A

C4BP

48
Q

Splits c4 convertase

A

C4BP

49
Q

Protectin

A

CD59

50
Q

Vitronectin

A

S protein

51
Q

Inhibits formation of MAC by binding c5b678

A

Protectin and vitronectin

52
Q

Present of self cells to prevent complement from damaging them

A

Protectin and vitronectin

53
Q

Inhibits MAC formation

A

Homologous restriction factor

54
Q

Proteolytically cleaves the anaphylotoxins

A

Anaphylotoxin inhibitor

55
Q

Most severe complement deficiency

A

Deficiency of c3

56
Q

Deficiency of c5-c8 and mannan binding lectin

A

Predispose to severe neisseria bacteremia

57
Q

Deficiency of c1 to esterase inhibitor

A

Angioedema

Inc capillary permeability

58
Q

Paroxysmal nocturnal hemoglobinuria dse

A

Marcha-fava Mitcheli syndrome

59
Q

Only hemolytic anemia acquired

A

Paroxysmal nocturnal hemoglobinuria

60
Q

Defect in intrinsic factor which os glycophosphatidyl inositol (red urine)

A

Paroxysmal nocturnal hemoglobinuria

61
Q

Measures over all complement activity of classical and alternative pathway

A

CH50 and AH50

62
Q

Measures total classical pathway

A

CH50

immunoserology (3 decks)

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